Title |
Requirement of ATM-dependent pathway for the repair of a subset of DNA double strand breaks created by restriction endonucleases
|
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Published in |
Genome Integrity, May 2010
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DOI | 10.1186/2041-9414-1-4 |
Pubmed ID | |
Authors |
Keiji Suzuki, Maiko Takahashi, Yasuyoshi Oka, Motohiro Yamauchi, Masatoshi Suzuki, Shunichi Yamashita |
Abstract |
DNA double strand breaks induced by DNA damaging agents, such ionizing radiation, are repaired by multiple DNA repair pathways including non-homologous end-joining (NHEJ) repair and homologous recombination (HR) repair. ATM-dependent DNA damage checkpoint regulates a part of DNA repair pathways, however, the exact role of ATM activity remains to be elucidated. In order to define the molecular structure of DNA double strand breaks requiring ATM activity we examined repair of DNA double strand breaks induced by different restriction endonucleases in normal human diploid cells treated with or without ATM-specific inhibitor. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 8 | 38% |
Student > Ph. D. Student | 4 | 19% |
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Student > Master | 1 | 5% |
Other | 1 | 5% |
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Medicine and Dentistry | 1 | 5% |
Other | 0 | 0% |
Unknown | 2 | 10% |