Title |
Estimated Effect of Inactivated Poliovirus Vaccine Campaigns, Nigeria and Pakistan, January 2014–April 2016
|
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Published in |
Emerging Infectious Diseases, February 2017
|
DOI | 10.3201/eid2302.161210 |
Pubmed ID | |
Authors |
George Shirreff, Zubair Wadood, Rui Gama Vaz, Roland W. Sutter, Nicholas C. Grassly |
Abstract |
In 2014, inactivated poliovirus vaccine (IPV) campaigns were implemented in Nigeria and Pakistan after clinical trials showed that IPV boosts intestinal immunity in children previously given oral poliovirus vaccine (OPV). We estimated the effect of these campaigns by using surveillance data collected during January 2014-April 2016. In Nigeria, campaigns with IPV and trivalent OPV (tOPV) substantially reduced the incidence of poliomyelitis caused by circulating serotype-2 vaccine-derived poliovirus (incidence rate ratio [IRR] 0.17 for 90 days after vs. 90 days before campaigns, 95% CI 0.04-0.78) and the prevalence of virus in environmental samples (prevalence ratio [PR] 0.16, 95% CI 0.02-1.33). Campaigns with tOPV alone resulted in similar reductions (IRR 0.59, 95% CI 0.18-1.97; PR 0.45, 95% CI 0.21-0.95). In Pakistan, the effect of IPV+tOPV campaigns on wild-type poliovirus was not significant. Results suggest that administration of IPV alongside OPV can decrease poliovirus transmission if high vaccine coverage is achieved. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 20% |
United States | 3 | 20% |
India | 1 | 7% |
Brazil | 1 | 7% |
Pakistan | 1 | 7% |
Unknown | 6 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 67% |
Scientists | 2 | 13% |
Practitioners (doctors, other healthcare professionals) | 2 | 13% |
Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 46 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 26% |
Student > Ph. D. Student | 6 | 13% |
Student > Master | 5 | 11% |
Student > Doctoral Student | 3 | 7% |
Other | 2 | 4% |
Other | 3 | 7% |
Unknown | 15 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 22% |
Social Sciences | 6 | 13% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Immunology and Microbiology | 2 | 4% |
Computer Science | 1 | 2% |
Other | 6 | 13% |
Unknown | 19 | 41% |