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Functional and comparative genomics analyses of pmp22 in medaka fish

Overview of attention for article published in BMC Neuroscience, January 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

blogs
1 blog

Citations

dimensions_citation
5 Dimensions

Readers on

mendeley
30 Mendeley
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Title
Functional and comparative genomics analyses of pmp22 in medaka fish
Published in
BMC Neuroscience, January 2009
DOI 10.1186/1471-2202-10-60
Pubmed ID
Authors

Junji Itou, Mikita Suyama, Yukio Imamura, Tomonori Deguchi, Kazuhiro Fujimori, Shunsuke Yuba, Yutaka Kawarabayasi, Takashi Kawasaki

Abstract

Pmp22, a member of the junction protein family Claudin/EMP/PMP22, plays an important role in myelin formation. Increase of pmp22 transcription causes peripheral neuropathy, Charcot-Marie-Tooth disease type1A (CMT1A). The pathophysiological phenotype of CMT1A is aberrant axonal myelination which induces a reduction in nerve conduction velocity (NCV). Several CMT1A model rodents have been established by overexpressing pmp22. Thus, it is thought that pmp22 expression must be tightly regulated for correct myelin formation in mammals. Interestingly, the myelin sheath is also present in other jawed vertebrates. The purpose of this study is to analyze the evolutionary conservation of the association between pmp22 transcription level and vertebrate myelin formation, and to find the conserved non-coding sequences for pmp22 regulation by comparative genomics analyses between jawed fishes and mammals.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Germany 1 3%
Unknown 28 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 20%
Researcher 5 17%
Professor 4 13%
Professor > Associate Professor 3 10%
Student > Bachelor 3 10%
Other 8 27%
Unknown 1 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 43%
Biochemistry, Genetics and Molecular Biology 4 13%
Medicine and Dentistry 3 10%
Computer Science 1 3%
Nursing and Health Professions 1 3%
Other 5 17%
Unknown 3 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2009.
All research outputs
#535,588
of 3,685,110 outputs
Outputs from BMC Neuroscience
#62
of 572 outputs
Outputs of similar age
#14,831
of 85,769 outputs
Outputs of similar age from BMC Neuroscience
#3
of 33 outputs
Altmetric has tracked 3,685,110 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 572 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 85,769 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.