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Tetherin restricts direct cell-to-cell infection of HIV-1

Overview of attention for article published in Retrovirology, January 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)

Mentioned by

blogs
1 blog

Citations

dimensions_citation
73 Dimensions

Readers on

mendeley
67 Mendeley
citeulike
1 CiteULike
connotea
1 Connotea
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Title
Tetherin restricts direct cell-to-cell infection of HIV-1
Published in
Retrovirology, January 2010
DOI 10.1186/1742-4690-7-115
Pubmed ID
Authors

Björn D Kuhl, Richard D Sloan, Daniel A Donahue, Tamara Bar-Magen, Chen Liang, Mark A Wainberg

Abstract

Tetherin (BST-2/CD317/HM1.24) is an interferon (IFN)-inducible factor of the innate immune system, recently shown to exert antiviral activity against HIV-1 and other enveloped viruses by tethering nascent viral particles to the cell surface, thereby inhibiting viral release. In HIV-1 infection, the viral protein U (Vpu) counteracts this antiviral action by down-modulating tetherin from the cell surface. Viral dissemination between T-cells can occur via cell-free transmission or the more efficient direct cell-to-cell route through lipid raft-rich virological synapses, to which tetherin localizes.

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Canada 1 1%
United Kingdom 1 1%
Japan 1 1%
Germany 1 1%
Unknown 61 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 30%
Researcher 18 27%
Student > Master 6 9%
Professor > Associate Professor 5 7%
Professor 4 6%
Other 9 13%
Unknown 5 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 34 51%
Immunology and Microbiology 11 16%
Biochemistry, Genetics and Molecular Biology 8 12%
Medicine and Dentistry 3 4%
Nursing and Health Professions 1 1%
Other 3 4%
Unknown 7 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2011.
All research outputs
#1,474,230
of 12,472,057 outputs
Outputs from Retrovirology
#74
of 715 outputs
Outputs of similar age
#19,017
of 144,053 outputs
Outputs of similar age from Retrovirology
#1
of 1 outputs
Altmetric has tracked 12,472,057 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 715 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 144,053 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them