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Dynasore Protects Mitochondria and Improves Cardiac Lusitropy in Langendorff Perfused Mouse Heart

Overview of attention for article published in PLOS ONE, April 2013
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Title
Dynasore Protects Mitochondria and Improves Cardiac Lusitropy in Langendorff Perfused Mouse Heart
Published in
PLOS ONE, April 2013
DOI 10.1371/journal.pone.0060967
Pubmed ID
Authors

Danchen Gao, Li Zhang, Ranvir Dhillon, Ting-Ting Hong, Robin M. Shaw, Jianhua Zhu

Abstract

Heart failure due to diastolic dysfunction exacts a major economic, morbidity and mortality burden in the United States. Therapeutic agents to improve diastolic dysfunction are limited. It was recently found that Dynamin related protein 1 (Drp1) mediates mitochondrial fission during ischemia/reperfusion (I/R) injury, whereas inhibition of Drp1 decreases myocardial infarct size. We hypothesized that Dynasore, a small noncompetitive dynamin GTPase inhibitor, could have beneficial effects on cardiac physiology during I/R injury.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Turkey 1 2%
Switzerland 1 2%
Unknown 55 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 19%
Researcher 6 11%
Student > Bachelor 6 11%
Student > Master 5 9%
Student > Postgraduate 4 7%
Other 9 16%
Unknown 16 28%
Readers by discipline Count As %
Medicine and Dentistry 16 28%
Biochemistry, Genetics and Molecular Biology 9 16%
Agricultural and Biological Sciences 5 9%
Immunology and Microbiology 3 5%
Chemistry 3 5%
Other 6 11%
Unknown 15 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2013.
All research outputs
#17,686,611
of 22,707,247 outputs
Outputs from PLOS ONE
#146,570
of 193,889 outputs
Outputs of similar age
#142,843
of 197,213 outputs
Outputs of similar age from PLOS ONE
#3,548
of 5,064 outputs
Altmetric has tracked 22,707,247 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,889 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,213 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5,064 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.