Title |
Eliciting candidate anatomical routes for protein interactions: a scenario from endocrine physiology
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Published in |
BMC Bioinformatics, April 2013
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DOI | 10.1186/1471-2105-14-131 |
Pubmed ID | |
Authors |
Pierre Grenon, Bernard de Bono |
Abstract |
In this paper, we use: i) formalised anatomical knowledge of connectivity between body structures and ii) a formal theory of physiological transport between fluid compartments in order to define and make explicit the routes followed by proteins to a site of interaction. The underlying processes are the objects of mathematical models of physiology and, therefore, the motivation for the approach can be understood as using knowledge representation and reasoning methods to propose concrete candidate routes corresponding to correlations between variables in mathematical models of physiology. In so doing, the approach projects physiology models onto a representation of the anatomical and physiological reality which underpins them. |
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United States | 1 | 50% |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
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Unknown | 8 | 100% |
Demographic breakdown
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Researcher | 4 | 50% |
Student > Ph. D. Student | 2 | 25% |
Professor > Associate Professor | 1 | 13% |
Professor | 1 | 13% |
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Agricultural and Biological Sciences | 4 | 50% |
Computer Science | 3 | 38% |
Engineering | 1 | 13% |