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Hybrid Approach for Predicting Coreceptor Used by HIV-1 from Its V3 Loop Amino Acid Sequence

Overview of attention for article published in PLOS ONE, April 2013
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Mentioned by

twitter
1 X user
facebook
1 Facebook page
googleplus
1 Google+ user
reddit
1 Redditor

Citations

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17 Dimensions

Readers on

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36 Mendeley
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1 CiteULike
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Title
Hybrid Approach for Predicting Coreceptor Used by HIV-1 from Its V3 Loop Amino Acid Sequence
Published in
PLOS ONE, April 2013
DOI 10.1371/journal.pone.0061437
Pubmed ID
Authors

Ravi Kumar, Gajendra P. S. Raghava

Abstract

HIV-1 infects the host cell by interacting with the primary receptor CD4 and a coreceptor CCR5 or CXCR4. Maraviroc, a CCR5 antagonist binds to CCR5 receptor. Thus, it is important to identify the coreceptor used by the HIV strains dominating in the patient. In past, a number of experimental assays and in-silico techniques have been developed for predicting the coreceptor tropism. The prediction accuracy of these methods is excellent when predicting CCR5(R5) tropic sequences but is relatively poor for CXCR4(X4) tropic sequences. Therefore, any new method for accurate determination of coreceptor usage would be of paramount importance to the successful management of HIV-infected individuals.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 3%
France 1 3%
Canada 1 3%
Unknown 33 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 19%
Researcher 7 19%
Student > Master 7 19%
Student > Bachelor 3 8%
Professor 2 6%
Other 3 8%
Unknown 7 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 25%
Biochemistry, Genetics and Molecular Biology 8 22%
Medicine and Dentistry 6 17%
Chemical Engineering 1 3%
Computer Science 1 3%
Other 3 8%
Unknown 8 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2013.
All research outputs
#12,875,359
of 22,707,247 outputs
Outputs from PLOS ONE
#100,431
of 193,889 outputs
Outputs of similar age
#100,686
of 197,213 outputs
Outputs of similar age from PLOS ONE
#2,425
of 5,064 outputs
Altmetric has tracked 22,707,247 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,889 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,213 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5,064 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.