Title |
Multiphasic analysis of the temporal development of the distal gut microbiota in patients following ileal pouch anal anastomosis
|
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Published in |
Microbiome, March 2013
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DOI | 10.1186/2049-2618-1-9 |
Pubmed ID | |
Authors |
Vincent B Young, Laura H Raffals, Susan M Huse, Marius Vital, Dongjuan Dai, Patrick D Schloss, Jennifer M Brulc, Dionysios A Antonopoulos, Rose L Arrieta, John H Kwon, K Gautham Reddy, Nathaniel A Hubert, Sharon L Grim, Joseph H Vineis, Sushila Dalal, Hilary G Morrison, A Murat Eren, Folker Meyer, Thomas M Schmidt, James M Tiedje, Eugene B Chang, Mitchell L Sogin |
Abstract |
The indigenous gut microbiota are thought to play a crucial role in the development and maintenance of the abnormal inflammatory responses that are the hallmark of inflammatory bowel disease. Direct tests of the role of the gut microbiome in these disorders are typically limited by the fact that sampling of the microbiota generally occurs once disease has become manifest. This limitation could potentially be circumvented by studying patients who undergo total proctocolectomy with ileal pouch anal anastomosis (IPAA) for the definitive treatment of ulcerative colitis. A subset of patients who undergo IPAA develops an inflammatory condition known as pouchitis, which is thought to mirror the pathogenesis of ulcerative colitis. Following the development of the microbiome of the pouch would allow characterization of the microbial community that predates the development of overt disease. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
Sweden | 1 | <1% |
Germany | 1 | <1% |
Unknown | 109 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 27 | 24% |
Student > Ph. D. Student | 20 | 18% |
Student > Master | 11 | 10% |
Professor > Associate Professor | 7 | 6% |
Student > Doctoral Student | 7 | 6% |
Other | 24 | 21% |
Unknown | 17 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 22% |
Agricultural and Biological Sciences | 23 | 20% |
Immunology and Microbiology | 10 | 9% |
Biochemistry, Genetics and Molecular Biology | 9 | 8% |
Environmental Science | 6 | 5% |
Other | 17 | 15% |
Unknown | 23 | 20% |