Title |
Low level β-lactamase production in methicillin-resistant staphylococcus aureus strains with β-lactam antibiotics-induced vancomycin resistance
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Published in |
BMC Microbiology, May 2012
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DOI | 10.1186/1471-2180-12-69 |
Pubmed ID | |
Authors |
Yuriko Hirao, Yurika Ikeda-Dantsuji, Hidehito Matsui, Masaki Yoshida, Seiji Hori, Keisuke Sunakawa, Taiji Nakae, Hideaki Hanaki |
Abstract |
A class of methicillin-resistant Staphylococcus aureus (MRSA) shows resistance to vancomycin only in the presence of ß-lactam antibiotics (BIVR). This type of vancomycin resistance is mainly attributable to the rapid depletion of free vancomycin in the presence of ß-lactam antibiotics. This means that ß-lactam antibiotics remain active or intact in BIVR culture, although most MRSA cells are assumed to produce ß-lactamase. We hypothesised that the BIVR cells either did not harbour the ß-lactamase gene, blaZ, or the gene was quiescent. We tested this hypothesis by determining ß-lactamase activity and conducting PCR amplification of blaZ. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 50% |
Japan | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 3% |
India | 1 | 3% |
Unknown | 29 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 16% |
Student > Postgraduate | 4 | 13% |
Student > Bachelor | 4 | 13% |
Student > Doctoral Student | 3 | 10% |
Student > Master | 3 | 10% |
Other | 7 | 23% |
Unknown | 5 | 16% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 35% |
Agricultural and Biological Sciences | 5 | 16% |
Immunology and Microbiology | 3 | 10% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Unspecified | 1 | 3% |
Other | 1 | 3% |
Unknown | 8 | 26% |