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Antifatigue Effects of Panax ginseng C.A. Meyer: A Randomised, Double-Blind, Placebo-Controlled Trial

Overview of attention for article published in PLOS ONE, April 2013
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
12 news outlets
twitter
9 X users
patent
1 patent
facebook
7 Facebook pages
reddit
1 Redditor
video
2 YouTube creators

Citations

dimensions_citation
97 Dimensions

Readers on

mendeley
194 Mendeley
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Title
Antifatigue Effects of Panax ginseng C.A. Meyer: A Randomised, Double-Blind, Placebo-Controlled Trial
Published in
PLOS ONE, April 2013
DOI 10.1371/journal.pone.0061271
Pubmed ID
Authors

Hyeong-Geug Kim, Jung-Hyo Cho, Sa-Ra Yoo, Jin-Seok Lee, Jong-Min Han, Nam-Hun Lee, Yo-Chan Ahn, Chang-Gue Son

Abstract

The present study investigated the antifatigue effects of Panax ginseng C.A. Meyer in 90 subjects (21 men and 69 women) with idiopathic chronic fatigue (ICF) in a randomised, double-blind, placebo-controlled and parallel designed trial. A bespoke 20% ethanol extract of P. ginseng (1 g or 2 g day(-1)) or a placebo was administered to each group for 4 weeks, and then fatigue severity was monitored using a self-rating numeric scale (NRS) and a visual analogue scale (VAS) as a primary endpoint. Serum levels of reactive oxygen species (ROS), malondialdehyde (MDA), total glutathione (GSH) contents and glutathione reductase (GSH-Rd) activity were determined. After 4-week, P. ginseng administration decreased the total NRS score, but they were not statistically significant compared with placebo (P>0.05). Mental NRS score was significantly improved by P. ginseng administrations as 20.4 ± 5.0 to 15.1 ± 6.5 [95% CI 2.3 ~ 8.2] for 1 g and 20.7 ± 6.3 to 13.8 ± 6.2 [95% CI -0.1 ~ 4.2] for 2 g compared with placebo 20.9 ± 4.5 to 18.8 ± 2.9 [95% CI 4.1 ~ 9.9, P<0.01]. Only 2 g P. ginseng significantly reduced the VAS score from 7.3 ± 1.3 to 4.4 ± 1.8 [95% CI 0.7∼1.8] compared with the placebo 7.1 ± 1.0 to 5.8 ± 1.3 [95% CI 2.2 ~ 3.7, P<0.01]. ROS and MDA levels were lowered by P. ginseng compared to placebo. P. ginseng 1 g increased GSH concentration and GSH-Rd activity. Our results provide the first evidence of the antifatigue effects of P. ginseng in patients with ICF, and we submit that these changes in antioxidant properties contribute in part to its mechanism.

X Demographics

X Demographics

The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 194 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 2 1%
United States 1 <1%
Chile 1 <1%
Unknown 190 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 61 31%
Student > Master 19 10%
Other 17 9%
Researcher 14 7%
Student > Ph. D. Student 12 6%
Other 28 14%
Unknown 43 22%
Readers by discipline Count As %
Medicine and Dentistry 58 30%
Nursing and Health Professions 21 11%
Agricultural and Biological Sciences 18 9%
Pharmacology, Toxicology and Pharmaceutical Science 14 7%
Biochemistry, Genetics and Molecular Biology 13 7%
Other 23 12%
Unknown 47 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 112. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2024.
All research outputs
#382,325
of 25,765,370 outputs
Outputs from PLOS ONE
#5,425
of 224,606 outputs
Outputs of similar age
#2,498
of 210,584 outputs
Outputs of similar age from PLOS ONE
#116
of 5,160 outputs
Altmetric has tracked 25,765,370 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 224,606 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,584 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 5,160 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.