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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Superresolution Imaging of Amyloid Fibrils with Binding-Activated Probes
|
|---|---|
| Published in |
ACS Chemical Neuroscience, April 2013
|
| DOI | 10.1021/cn400091m |
| Pubmed ID | |
| Authors |
Jonas Ries, Vinod Udayar, Alice Soragni, Simone Hornemann, K. Peter R. Nilsson, Roland Riek, Christoph Hock, Helge Ewers, Adriano A. Aguzzi, Lawrence Rajendran |
| Abstract |
Protein misfolding into amyloid-like aggregates underlies many neurodegenerative diseases. Thus, insights into the structure and function of these amyloids will provide valuable information on the pathological mechanisms involved and aid in the design of improved drugs for treating amyloid-based disorders. However, determining the structure of endogenous amyloids at high resolution has been difficult. Here we employ binding-activated localization microscopy (BALM) to acquire superresolution images of α-synuclein amyloid fibrils with unprecedented optical resolution. We propose that BALM imaging can be extended to study the structure of other amyloids, for differential diagnosis of amyloid-related diseases and for discovery of drugs that perturb amyloid structure for therapy. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| Czechia | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 143 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 46 | 31% |
| Student > Ph. D. Student | 35 | 24% |
| Student > Bachelor | 10 | 7% |
| Professor | 9 | 6% |
| Student > Doctoral Student | 8 | 5% |
| Other | 19 | 13% |
| Unknown | 20 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 30 | 20% |
| Chemistry | 30 | 20% |
| Biochemistry, Genetics and Molecular Biology | 22 | 15% |
| Physics and Astronomy | 12 | 8% |
| Engineering | 9 | 6% |
| Other | 18 | 12% |
| Unknown | 26 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2020.
All research outputs
#2,485,770
of 25,374,917 outputs
Outputs from ACS Chemical Neuroscience
#289
of 2,749 outputs
Outputs of similar age
#20,364
of 208,646 outputs
Outputs of similar age from ACS Chemical Neuroscience
#2
of 30 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,749 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,646 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.