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Danazol for pelvic pain associated with endometriosis

Overview of attention for article published in Cochrane database of systematic reviews, October 2007
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  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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3 tweeters
wikipedia
1 Wikipedia page

Citations

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89 Dimensions

Readers on

mendeley
109 Mendeley
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Title
Danazol for pelvic pain associated with endometriosis
Published in
Cochrane database of systematic reviews, October 2007
DOI 10.1002/14651858.cd000068.pub2
Pubmed ID
Authors

Cindy Farquhar, Andrew Prentice, Amita A Singla, Vanessa Selak

Abstract

Endometriosis is defined as the presence of endometrial tissue (stromal and glandular) outside the normal uterine cavity. Conventional medical and surgical treatments for endometriosis aim to remove or decrease the deposits of ectopic endometrium. The observation that hyper androgenic states (an excess of male hormone) induce atrophy of the endometrium has led to the use of androgens in the treatment of endometriosis. Danazol is one of these treatments. The efficacy of danazol is based on its ability to produce a high androgen and low oestrogen environment (a pseudo menopause) which results in atrophy of the endometriotic implants and thus an improvement in painful symptoms. To determine the effectiveness of danazol compared to placebo or no treatment in the treatment of the symptoms and signs, other than infertility, of endometriosis in women of reproductive age. We searched the Cochrane Menstrual Disorders and Subfertility Group Specialised Register of trials (searched April 2007), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 2, 2007), and MEDLINE (1966 to April 2007). In addition, all reference lists of included trials were searched, and relevant drug companies were contacted for details of unpublished trials. Randomised controlled trials in which danazol (alone or as adjunctive therapy) was compared to placebo or no therapy. Trials which only reported infertility outcomes were excluded. Only five trials met the inclusion criteria and two authors independently extracted data from these trials. All trials compared danazol to placebo. Three trials used danazol as sole therapy and three trials used danazol as an adjunct to surgery. Although the main outcome was pain improvement other data relating to laparoscopic scores and hormonal parameters were also collected. Treatment with danazol (including adjunctive to surgical therapy) was effective in relieving painful symptoms related to endometriosis when compared to placebo. Laparoscopic scores were improved with danazol treatment (including as adjunctive therapy) when compared with either placebo or no treatment. Side effects were more commonly reported in those patients receiving danazol than for placebo. Danazol is effective in treating the symptoms and signs of endometriosis. However, its use is limited by the occurrence of androgenic side effects.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
United States 1 <1%
Sweden 1 <1%
South Africa 1 <1%
Unknown 105 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 21 19%
Researcher 18 17%
Student > Bachelor 17 16%
Student > Doctoral Student 12 11%
Student > Ph. D. Student 10 9%
Other 21 19%
Unknown 10 9%
Readers by discipline Count As %
Medicine and Dentistry 55 50%
Agricultural and Biological Sciences 7 6%
Nursing and Health Professions 7 6%
Biochemistry, Genetics and Molecular Biology 5 5%
Pharmacology, Toxicology and Pharmaceutical Science 4 4%
Other 17 16%
Unknown 14 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2020.
All research outputs
#3,772,975
of 14,480,277 outputs
Outputs from Cochrane database of systematic reviews
#6,554
of 10,982 outputs
Outputs of similar age
#37,182
of 151,723 outputs
Outputs of similar age from Cochrane database of systematic reviews
#37
of 67 outputs
Altmetric has tracked 14,480,277 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 10,982 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.0. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 151,723 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.