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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Altered Expression of Type-1 and Type-2 Cannabinoid Receptors in Celiac Disease
|
|---|---|
| Published in |
PLOS ONE, April 2013
|
| DOI | 10.1371/journal.pone.0062078 |
| Pubmed ID | |
| Authors |
Natalia Battista, Antonio Di Sabatino, Monia Di Tommaso, Paolo Biancheri, Cinzia Rapino, Paolo Giuffrida, Cinzia Papadia, Chiara Montana, Alessandra Pasini, Alessandro Vanoli, Francesco Lanzarotto, Vincenzo Villanacci, Gino R. Corazza, Mauro Maccarrone |
| Abstract |
Anandamide (AEA) is the prominent member of the endocannabinoid family and its biological action is mediated through the binding to both type-1 (CB1) and type-2 (CB2) cannabinoid receptors (CBR). The presence of AEA and CBR in the gastrointestinal tract highlighted their pathophysiological role in several gut diseases, including celiac disease. Here, we aimed to investigate the expression of CBR at transcriptional and translational levels in the duodenal mucosa of untreated celiac patients, celiac patients on a gluten-free diet for at least 12 months and control subjects. Also biopsies from treated celiac patients cultured ex vivo with peptic-tryptic digest of gliadin were investigated. Our data show higher levels of both CB1 and CB2 receptors during active disease and normal CBR levels in treated celiac patients. In conclusion, we demonstrate an up-regulation of CB1 and CB2 mRNA and protein expression, that points to the therapeutic potential of targeting CBR in patients with celiac disease. |
X Demographics
The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 23% |
| Turkey | 4 | 15% |
| Belgium | 1 | 4% |
| Chile | 1 | 4% |
| Unknown | 14 | 54% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 24 | 92% |
| Scientists | 1 | 4% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 4% |
| United Kingdom | 1 | 2% |
| Unknown | 50 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 17% |
| Student > Bachelor | 9 | 17% |
| Researcher | 8 | 15% |
| Student > Doctoral Student | 5 | 9% |
| Other | 3 | 6% |
| Other | 13 | 25% |
| Unknown | 6 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 36% |
| Agricultural and Biological Sciences | 9 | 17% |
| Biochemistry, Genetics and Molecular Biology | 7 | 13% |
| Psychology | 2 | 4% |
| Immunology and Microbiology | 2 | 4% |
| Other | 7 | 13% |
| Unknown | 7 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 October 2020.
All research outputs
#1,251,388
of 25,654,806 outputs
Outputs from PLOS ONE
#15,758
of 223,967 outputs
Outputs of similar age
#9,438
of 210,762 outputs
Outputs of similar age from PLOS ONE
#324
of 5,150 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 223,967 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,762 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 5,150 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.