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A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations

Overview of attention for article published in Retrovirology, January 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)

Mentioned by

news
1 news outlet
twitter
11 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
50 Dimensions

Readers on

mendeley
63 Mendeley
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Title
A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations
Published in
Retrovirology, January 2013
DOI 10.1186/1742-4690-10-43
Pubmed ID
Authors

Michael Roche, Hamid Salimi, Renee Duncan, Brendan L Wilkinson, Kelechi Chikere, Miranda S Moore, Nicholas E Webb, Helena Zappi, Jasminka Sterjovski, Jacqueline K Flynn, Anne Ellett, Lachlan R Gray, Benhur Lee, Becky Jubb, Mike Westby, Paul A Ramsland, Sharon R Lewin, Richard J Payne, Melissa J Churchill, Paul R Gorry

Abstract

The CCR5 antagonist maraviroc (MVC) inhibits human immunodeficiency virus type 1 (HIV-1) entry by altering the CCR5 extracellular loops (ECL), such that the gp120 envelope glycoproteins (Env) no longer recognize CCR5. The mechanisms of HIV-1 resistance to MVC, the only CCR5 antagonist licensed for clinical use are poorly understood, with insights into MVC resistance almost exclusively limited to knowledge obtained from in vitro studies or from studies of resistance to other CCR5 antagonists. To more precisely understand mechanisms of resistance to MVC in vivo, we characterized Envs isolated from 2 subjects who experienced virologic failure on MVC.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 2%
Brazil 1 2%
Unknown 61 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 17%
Student > Master 11 17%
Researcher 8 13%
Student > Bachelor 8 13%
Other 4 6%
Other 10 16%
Unknown 11 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 25%
Medicine and Dentistry 8 13%
Immunology and Microbiology 7 11%
Biochemistry, Genetics and Molecular Biology 7 11%
Chemistry 4 6%
Other 9 14%
Unknown 12 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2016.
All research outputs
#1,353,869
of 15,736,309 outputs
Outputs from Retrovirology
#60
of 885 outputs
Outputs of similar age
#14,370
of 156,485 outputs
Outputs of similar age from Retrovirology
#1
of 1 outputs
Altmetric has tracked 15,736,309 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 885 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 156,485 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them