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Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates

Overview of attention for article published in Revista Brasileira de Psiquiatria, August 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#38 of 915)
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

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4 news outlets
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1 Facebook page

Citations

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10 Dimensions

Readers on

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73 Mendeley
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Title
Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates
Published in
Revista Brasileira de Psiquiatria, August 2015
DOI 10.1590/1516-4446-2014-1619
Pubmed ID
Authors

Christine Lochner, Nathaniel McGregor, Sian Hemmings, Brian H. Harvey, Elsie Breet, Sonja Swanevelder, Dan J. Stein

Abstract

In obsessive-compulsive disorder (OCD), symmetry-related symptoms may be important. Although clinical correlates of symmetry-related symptoms have been identified in OCD, few data exist on genetic associations. Animal studies indicate involvement of dopamine in symmetry-related behavior, suggesting this may be relevant to analogous symptoms in OCD. Alterations in dopamine may also reflect environmental influences. However, the association of symmetry-related symptomatology, early adversity, and polymorphisms in dopaminergic genes has not been investigated in OCD. Clinical information and polymorphisms in key dopaminergic genes were compared between OCD patients with primary symmetry symptoms and those without. OCD patients with primary symmetry symptoms comprised 46.6% (n=210) of the sample (n=451), and were older (p < 0.01), had longer illness duration (p < 0.01), higher OCD severity scores (p = 0.01), and greater comorbidity (p < 0.01) than those without. In Caucasians (n=343), genotype frequency differed significantly between groups for ANKK1 rs1800497, with more OCD patients with symmetry symptoms being homozygous for the A2 (CC) genotype (χ2 = 7.296; p = 0.026). Symmetry symptoms have some distinct clinical features and may represent a marker of severity in OCD. However, clinical associations, in combination with the association found with the ANKK1 rs1800497 A2 variant, suggest that primary symmetry symptoms may represent a distinctive clinical and psychobiological profile.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 1 1%
Unknown 72 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 12%
Researcher 9 12%
Student > Ph. D. Student 9 12%
Student > Bachelor 7 10%
Professor 4 5%
Other 10 14%
Unknown 25 34%
Readers by discipline Count As %
Psychology 15 21%
Medicine and Dentistry 7 10%
Neuroscience 7 10%
Agricultural and Biological Sciences 3 4%
Biochemistry, Genetics and Molecular Biology 3 4%
Other 8 11%
Unknown 30 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 June 2023.
All research outputs
#1,500,449
of 26,161,782 outputs
Outputs from Revista Brasileira de Psiquiatria
#38
of 915 outputs
Outputs of similar age
#18,903
of 279,240 outputs
Outputs of similar age from Revista Brasileira de Psiquiatria
#1
of 12 outputs
Altmetric has tracked 26,161,782 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 915 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,240 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.