Title |
Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates
|
---|---|
Published in |
Revista Brasileira de Psiquiatria, August 2015
|
DOI | 10.1590/1516-4446-2014-1619 |
Pubmed ID | |
Authors |
Christine Lochner, Nathaniel McGregor, Sian Hemmings, Brian H. Harvey, Elsie Breet, Sonja Swanevelder, Dan J. Stein |
Abstract |
In obsessive-compulsive disorder (OCD), symmetry-related symptoms may be important. Although clinical correlates of symmetry-related symptoms have been identified in OCD, few data exist on genetic associations. Animal studies indicate involvement of dopamine in symmetry-related behavior, suggesting this may be relevant to analogous symptoms in OCD. Alterations in dopamine may also reflect environmental influences. However, the association of symmetry-related symptomatology, early adversity, and polymorphisms in dopaminergic genes has not been investigated in OCD. Clinical information and polymorphisms in key dopaminergic genes were compared between OCD patients with primary symmetry symptoms and those without. OCD patients with primary symmetry symptoms comprised 46.6% (n=210) of the sample (n=451), and were older (p < 0.01), had longer illness duration (p < 0.01), higher OCD severity scores (p = 0.01), and greater comorbidity (p < 0.01) than those without. In Caucasians (n=343), genotype frequency differed significantly between groups for ANKK1 rs1800497, with more OCD patients with symmetry symptoms being homozygous for the A2 (CC) genotype (χ2 = 7.296; p = 0.026). Symmetry symptoms have some distinct clinical features and may represent a marker of severity in OCD. However, clinical associations, in combination with the association found with the ANKK1 rs1800497 A2 variant, suggest that primary symmetry symptoms may represent a distinctive clinical and psychobiological profile. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
South Africa | 1 | 1% |
Unknown | 72 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 12% |
Researcher | 9 | 12% |
Student > Ph. D. Student | 9 | 12% |
Student > Bachelor | 7 | 10% |
Professor | 4 | 5% |
Other | 10 | 14% |
Unknown | 25 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 15 | 21% |
Medicine and Dentistry | 7 | 10% |
Neuroscience | 7 | 10% |
Agricultural and Biological Sciences | 3 | 4% |
Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Other | 8 | 11% |
Unknown | 30 | 41% |