Title |
In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells
|
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Published in |
BMC Cancer, April 2013
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DOI | 10.1186/1471-2407-13-198 |
Pubmed ID | |
Authors |
Drazen B Zimonjic, Lai N Chan, Veenu Tripathi, Jie Lu, Ohyun Kwon, Nicholas C Popescu, Douglas R Lowy, Fuyuhiko Tamanoi |
Abstract |
Lung cancer is the leading cause of cancer-related mortality. Therapies against non-small cell lung cancer (NSCLC) are particularly needed, as this type of cancer is relatively insensitive to chemotherapy and radiation therapy. We recently identified GGTI compounds that are designed to block geranylgeranylation and membrane association of signaling proteins including the Rho family G-proteins. One of the GGTIs is P61A6 which inhibits proliferation of human cancer cells, causes cell cycle effects with G1 accumulation and exhibits tumor-suppressing effects with human pancreatic cancer xenografts. In this paper, we investigated effects of P61A6 on non-small cell lung cancer (NSCLC) cells in vitro and in vivo. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 5 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 18% |
Student > Postgraduate | 3 | 9% |
Student > Doctoral Student | 2 | 6% |
Professor | 2 | 6% |
Student > Master | 2 | 6% |
Other | 4 | 12% |
Unknown | 14 | 42% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 15% |
Biochemistry, Genetics and Molecular Biology | 4 | 12% |
Agricultural and Biological Sciences | 4 | 12% |
Chemistry | 3 | 9% |
Unspecified | 1 | 3% |
Other | 2 | 6% |
Unknown | 14 | 42% |