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Application of the Immunoscore as prognostic tool for hepatocellular carcinoma

Overview of attention for article published in Journal for Immunotherapy of Cancer, November 2016
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Title
Application of the Immunoscore as prognostic tool for hepatocellular carcinoma
Published in
Journal for Immunotherapy of Cancer, November 2016
DOI 10.1186/s40425-016-0182-5
Pubmed ID
Authors

Annacarmen Petrizzo, Luigi Buonaguro

Abstract

To date, the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC) tumor, nodes, metastasis (TNM) classification represents the standard system for evaluation of prognosis in solid tumors. However, the clinical outcome can be significantly different in patients with the same TNM stage. Therefore, many efforts have been made aiming to define new prognostic parameters. Indeed, analyses conducted in large cohorts of colorectal cancer patients emphasized the prognostic value of tumor-infiltrating lymphocytes, leading to the development of a prognostic score referred to as "Immunoscore". In this commentary, we recapitulate the study by Gabrielson and colleagues, recently published in Cancer Immunology Research, addressing the role of intratumoral CD3(+) and CD8(+) T cells as well as as prognostic markers for hepatocellular carcinoma. The authors demonstrate that Immunoscore represents a valuable prognostic marker in patients with hepatocellular carcinoma who have undergone primary tumor resection, supporting its application in a tumor setting other than colorectal cancer.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 16%
Student > Ph. D. Student 5 13%
Student > Master 5 13%
Student > Doctoral Student 4 11%
Student > Bachelor 3 8%
Other 9 24%
Unknown 6 16%
Readers by discipline Count As %
Medicine and Dentistry 18 47%
Nursing and Health Professions 4 11%
Biochemistry, Genetics and Molecular Biology 3 8%
Agricultural and Biological Sciences 3 8%
Immunology and Microbiology 2 5%
Other 1 3%
Unknown 7 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2016.
All research outputs
#14,278,325
of 25,374,917 outputs
Outputs from Journal for Immunotherapy of Cancer
#2,257
of 3,421 outputs
Outputs of similar age
#159,124
of 311,953 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#24
of 33 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,421 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.4. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 311,953 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.