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Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behavior

Overview of attention for article published in Journal of Neuroinflammation, April 2013
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Citations

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58 Mendeley
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Title
Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behavior
Published in
Journal of Neuroinflammation, April 2013
DOI 10.1186/1742-2094-8-54
Pubmed ID
Authors

Michael D Burton, Nathan L Sparkman, Rodney W Johnson

Abstract

Interleukin (IL)-6 is produced in the brain during peripheral infection and plays an important but poorly understood role in sickness behavior. Therefore, this study investigated the capacity of soluble gp130 (sgp130), a natural inhibitor of the IL-6 trans-signaling pathway to regulate IL-6 production in microglia and neurons in vitro and its effects on lipopolysaccharide (LPS)-induced sickness behavior in vivo.

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 2%
Netherlands 1 2%
Sweden 1 2%
Mexico 1 2%
Russia 1 2%
Japan 1 2%
United States 1 2%
Unknown 51 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 17%
Researcher 10 17%
Student > Doctoral Student 8 14%
Student > Bachelor 6 10%
Student > Master 6 10%
Other 16 28%
Unknown 2 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 26%
Medicine and Dentistry 12 21%
Neuroscience 9 16%
Biochemistry, Genetics and Molecular Biology 8 14%
Computer Science 1 2%
Other 7 12%
Unknown 6 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 April 2013.
All research outputs
#2,015,998
of 3,617,832 outputs
Outputs from Journal of Neuroinflammation
#253
of 533 outputs
Outputs of similar age
#43,703
of 84,545 outputs
Outputs of similar age from Journal of Neuroinflammation
#21
of 41 outputs
Altmetric has tracked 3,617,832 research outputs across all sources so far. This one is in the 25th percentile – i.e., 25% of other outputs scored the same or lower than it.
So far Altmetric has tracked 533 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 84,545 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.