| Chapter title |
Gastrointestinal Physiology and Diseases
|
|---|---|
| Chapter number | 10 |
| Book title |
Gastrointestinal Physiology and Diseases
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3603-8_10 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3601-4, 978-1-4939-3603-8
|
| Authors |
Luo, Liping, Reedy, April R, Jones, Rheinallt M, Liping Luo, April R. Reedy, Rheinallt M. Jones Ph.D., Rheinallt M. Jones |
| Editors |
Andrei I. Ivanov |
| Abstract |
The conservation of intestinal stem cell crypt dynamics between Drosophila melanogaster and mammals allows for the genetically tractable fly model to be used for analyses of intestinal development, homeostasis, and renewal in relation to microbiota. The invertebrate fly model is advantageous for genetic research due to its anatomical and genetic simplicity and short lifespan. Accordingly, experimental resources such as large numbers of mutant and genetically modified flies have been developed. We have developed techniques to generate germ-free Drosophila, monoassociate them with candidate bacteria, and assess ensuing physiological responses within the gut tissue that include the generation of reactive oxygen species and cell proliferation. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 26% |
| Student > Master | 3 | 16% |
| Student > Ph. D. Student | 3 | 16% |
| Other | 2 | 11% |
| Professor | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 4 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 32% |
| Agricultural and Biological Sciences | 5 | 26% |
| Medicine and Dentistry | 1 | 5% |
| Unknown | 7 | 37% |