Title |
Radiation mitigating properties of the lignan component in flaxseed
|
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Published in |
BMC Cancer, April 2013
|
DOI | 10.1186/1471-2407-13-179 |
Pubmed ID | |
Authors |
Ralph Pietrofesa, Jason Turowski, Sonia Tyagi, Floyd Dukes, Evguenia Arguiri, Theresa M Busch, Shannon M Gallagher-Colombo, Charalambos C Solomides, Keith A Cengel, Melpo Christofidou-Solomidou |
Abstract |
Wholegrain flaxseed (FS), and its lignan component (FLC) consisting mainly of secoisolariciresinol diglucoside (SDG), have potent lung radioprotective properties while not abrogating the efficacy of radiotherapy. However, while the whole grain was recently shown to also have potent mitigating properties in a thoracic radiation pneumonopathy model, the bioactive component in the grain responsible for the mitigation of lung damage was never identified. Lungs may be exposed to radiation therapeutically for thoracic malignancies or incidentally following detonation of a radiological dispersion device. This could potentially lead to pulmonary inflammation, oxidative tissue injury, and fibrosis. This study aimed to evaluate the radiation mitigating effects of FLC in a mouse model of radiation pneumonopathy. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 45 | 100% |
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Student > Master | 7 | 16% |
Student > Ph. D. Student | 7 | 16% |
Student > Doctoral Student | 7 | 16% |
Researcher | 5 | 11% |
Lecturer | 3 | 7% |
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Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 7 | 16% |
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