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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Nasal administration of anti-CD3 mAb (Foralumab) downregulates NKG7 and increases TGFB1 and GIMAP7 expression in T cells in subjects with COVID-19
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, March 2023
|
| DOI | 10.1073/pnas.2220272120 |
| Pubmed ID | |
| Authors |
Thais G. Moreira, Christian D. Gauthier, Liam Murphy, Toby B. Lanser, Anu Paul, Kimble T. F. Matos, Davide Mangani, Saef Izzy, Rafael M. Rezende, Brian C. Healy, Clare M. Baecher-Allan, Tanuja Chitnis, Vijay Kuchroo, Howard L. Weiner |
| Abstract |
T cells are present in early stages of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and play a major role in disease outcome and long-lasting immunity. Nasal administration of a fully human anti-CD3 monoclonal antibody (Foralumab) reduced lung inflammation as well as serum IL-6 and C-reactive protein in moderate cases of COVID-19. Using serum proteomics and RNA-sequencing, we investigated the immune changes in patients treated with nasal Foralumab. In a randomized trial, mild to moderate COVID-19 outpatients received nasal Foralumab (100 μg/d) given for 10 consecutive days and were compared to patients that did not receive Foralumab. We found that naïve-like T cells were increased in Foralumab-treated subjects and NGK7+ effector T cells were reduced. CCL5, IL32, CST7, GZMH, GZMB, GZMA, PRF1, and CCL4 gene expression were downregulated in T cells and CASP1 was downregulated in T cells, monocytes, and B cells in subjects treated with Foralumab. In addition to the downregulation of effector features, an increase in TGFB1 gene expression in cell types with known effector function was observed in Foralumab-treated subjects. We also found increased expression of GTP-binding gene GIMAP7 in subjects treated with Foralumab. Rho/ROCK1, a downstream pathway of GTPases signaling was downregulated in Foralumab-treated individuals. TGFB1, GIMAP7, and NKG7 transcriptomic changes observed in Foralumab-treated COVID-19 subjects were also observed in healthy volunteers, MS subjects, and mice treated with nasal anti-CD3. Our findings demonstrate that nasal Foralumab modulates the inflammatory response in COVID-19 and provides a novel avenue to treat the disease. |
X Demographics
The data shown below were collected from the profiles of 280 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 40 | 14% |
| United Kingdom | 12 | 4% |
| Germany | 10 | 4% |
| Canada | 7 | 3% |
| Australia | 5 | 2% |
| Switzerland | 4 | 1% |
| Spain | 4 | 1% |
| Sweden | 3 | 1% |
| Mexico | 3 | 1% |
| Other | 27 | 10% |
| Unknown | 165 | 59% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 237 | 85% |
| Practitioners (doctors, other healthcare professionals) | 20 | 7% |
| Scientists | 20 | 7% |
| Science communicators (journalists, bloggers, editors) | 3 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 21% |
| Researcher | 3 | 16% |
| Unspecified | 2 | 11% |
| Student > Master | 2 | 11% |
| Professor | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 6 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 16% |
| Unspecified | 2 | 11% |
| Biochemistry, Genetics and Molecular Biology | 2 | 11% |
| Veterinary Science and Veterinary Medicine | 1 | 5% |
| Nursing and Health Professions | 1 | 5% |
| Other | 3 | 16% |
| Unknown | 7 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 749. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2024.
All research outputs
#26,924
of 25,784,004 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#815
of 103,739 outputs
Outputs of similar age
#760
of 426,884 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#21
of 890 outputs
Altmetric has tracked 25,784,004 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 103,739 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 426,884 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 890 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.