https://t.co/yLBSMJ1wbf "Evidence to this fact is the reduction in central nervous system (CNS) BH4 concentration after intramuscular injection of rat with IFN-α." "Besides, further inhibition of iNOS increases the production of NO shown to overturn the
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3,700 followers
https://t.co/yLBSMJ0YlH "The consequences of elevated ROS and iNOS result in decrease of BH4 through the production of oxygen free radicals instead of NO."
3,700 followers
https://t.co/yLBSMJ1wbf "However, these increased cytokines induced activity of GCH1 does not increase the production of 5-HT or dopamine since inflammation also induces the production of reactive oxygen species (ROS) and inducible NOS (iNOS)."
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https://t.co/yLBSMJ0YlH "Shoedon et al. have shown that when there is stimulation to the immune response, IFN-γ will induce GCH1 activity which will lead to increase in the synthesis of BH4."