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Complete sequences of six major histocompatibility complex haplotypes, including all the major MHC class II structures

Overview of attention for article published in HLA, March 2023
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  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#33 of 1,488)
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

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Title
Complete sequences of six major histocompatibility complex haplotypes, including all the major MHC class II structures
Published in
HLA, March 2023
DOI 10.1111/tan.15020
Pubmed ID
Authors

Torsten Houwaart, Stephan Scholz, Nicholas R. Pollock, William H. Palmer, Katherine M. Kichula, Daniel Strelow, Duyen B. Le, Dana Belick, Lisanna Hülse, Tobias Lautwein, Thorsten Wachtmeister, Tassilo E. Wollenweber, Birgit Henrich, Karl Köhrer, Peter Parham, Lisbeth A. Guethlein, Paul J. Norman, Alexander T. Dilthey

Abstract

Accurate and comprehensive immunogenetic reference panels are key to the successful implementation of population-scale immunogenomics. The 5Mbp Major Histocompatibility Complex (MHC) is the most polymorphic region of the human genome and associated with multiple immune-mediated diseases, transplant matching and therapy responses. Analysis of MHC genetic variation is severely complicated by complex patterns of sequence variation, linkage disequilibrium and a lack of fully resolved MHC reference haplotypes, increasing the risk of spurious findings on analyzing this medically important region. Integrating Illumina, ultra-long Nanopore, and PacBio HiFi sequencing as well as bespoke bioinformatics, we completed five of the alternative MHC reference haplotypes of the current (GRCh38/hg38) build of the human reference genome and added one other. The six assembled MHC haplotypes encompass the DR1 and DR4 haplotype structures in addition to the previously completed DR2 and DR3, as well as six distinct classes of the structurally variable C4 region. Analysis of the assembled haplotypes showed that MHC class II sequence structures, including repeat element positions, are generally conserved within the DR haplotype supergroups, and that sequence diversity peaks in three regions around HLA-A, HLA-B+C, and the HLA class II genes. Demonstrating the potential for improved short-read analysis, the number of proper read pairs recruited to the MHC was found to be increased by 0.06%-0.49% in a 1000 Genomes Project read remapping experiment with seven diverse samples. Furthermore, the assembled haplotypes can serve as references for the community and provide the basis of a structurally accurate genotyping graph of the complete MHC region.

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X Demographics

The data shown below were collected from the profiles of 27 X users who shared this research output. Click here to find out more about how the information was compiled.
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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 16%
Professor 3 16%
Unspecified 1 5%
Other 1 5%
Student > Doctoral Student 1 5%
Other 2 11%
Unknown 8 42%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 32%
Immunology and Microbiology 2 11%
Unspecified 1 5%
Engineering 1 5%
Unknown 9 47%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2024.
All research outputs
#2,562,857
of 26,510,312 outputs
Outputs from HLA
#33
of 1,488 outputs
Outputs of similar age
#51,518
of 444,771 outputs
Outputs of similar age from HLA
#2
of 14 outputs
Altmetric has tracked 26,510,312 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,488 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 444,771 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.