Title |
Type I Interferon Impairs Specific Antibody Responses Early during Establishment of LCMV Infection
|
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Published in |
Frontiers in immunology, December 2016
|
DOI | 10.3389/fimmu.2016.00564 |
Pubmed ID | |
Authors |
Matthieu Daugan, Armstrong Murira, Barbara C. Mindt, Amélie Germain, Esther Tarrab, Pascal Lapierre, Jörg H. Fritz, Alain Lamarre |
Abstract |
Elicitation of type I interferon (IFN-I) has been shown to both enhance and impair cell-mediated immune responses in acute and persistent viral infections, respectively. Here, we show that, in addition to its effect on T cells, IFN-I drives impairment of specific antibody responses through interaction with B cells in the acute phase of lymphocytic choriomeningitis virus (LCMV) infection. This impairment was limited to the T cell-dependent B cell response and was associated with disruption of B cell follicles, development of hypergammaglobulinemia (HGG), and expansion of the T follicular helper cell population. Antigen-specific antibody responses were restored by ablation of IFN-I signaling through antibody-mediated IFN-I receptor blockade and B cell-specific IFN-I receptor knockout. Importantly, IFN-I receptor deficiency in B cells also accelerated the development of LCMV neutralizing antibodies and alleviated HGG. These results provide a potential therapeutic target toward efficient treatment measures that limit immunopathology in persistent viral infections. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 3% |
Unknown | 38 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 26% |
Student > Doctoral Student | 4 | 10% |
Student > Bachelor | 3 | 8% |
Researcher | 3 | 8% |
Professor | 3 | 8% |
Other | 6 | 15% |
Unknown | 10 | 26% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 14 | 36% |
Agricultural and Biological Sciences | 7 | 18% |
Biochemistry, Genetics and Molecular Biology | 5 | 13% |
Medicine and Dentistry | 2 | 5% |
Unspecified | 1 | 3% |
Other | 0 | 0% |
Unknown | 10 | 26% |