You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
Attention Score in Context
| Title |
Transcriptional Repressor Gfi1 Integrates Cytokine-Receptor Signals Controlling B-Cell Differentiation
|
|---|---|
| Published in |
PLOS ONE, March 2007
|
| DOI | 10.1371/journal.pone.0000306 |
| Pubmed ID | |
| Authors |
Chozhavendan Rathinam, Christoph Klein |
| Abstract |
Hematopoietic stem cell differentiation is specified by cytokines and transcription factors, but the mechanisms controlling instructive and permissive signalling networks are poorly understood. We provide evidence that CLP1-dependent IL7-receptor mediated B cell differentiation is critically controlled by the transcriptional repressor Gfi1. Gfi1-deficient progenitor B cells show global defects in IL7Ralpha-dependent signal cascades. Consequently, IL7-dependent trophic, proliferative and differentiation-inducing responses of progenitor B cells are perturbed. Gfi1 directly regulates expression levels of IL7Ralpha and indirectly controls STAT5 signalling via expression of SOCS3. Thus, Gfi1 selectively specifies IL7-dependent development of B cells from CLP1 progenitors, providing clues to the transcriptional networks integrating cytokine signals and lymphoid differentiation. |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Turkey | 2 | 7% |
| United Kingdom | 1 | 3% |
| United States | 1 | 3% |
| Unknown | 26 | 87% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 30% |
| Student > Ph. D. Student | 3 | 10% |
| Professor | 3 | 10% |
| Professor > Associate Professor | 3 | 10% |
| Student > Master | 3 | 10% |
| Other | 8 | 27% |
| Unknown | 1 | 3% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 57% |
| Immunology and Microbiology | 3 | 10% |
| Biochemistry, Genetics and Molecular Biology | 2 | 7% |
| Social Sciences | 2 | 7% |
| Medicine and Dentistry | 2 | 7% |
| Other | 1 | 3% |
| Unknown | 3 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2012.
All research outputs
#3,259,353
of 22,709,015 outputs
Outputs from PLOS ONE
#42,843
of 193,901 outputs
Outputs of similar age
#8,618
of 76,774 outputs
Outputs of similar age from PLOS ONE
#45
of 143 outputs
Altmetric has tracked 22,709,015 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 193,901 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 76,774 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 143 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.