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Mendeley readers
Attention Score in Context
| Title |
Blunted Neuronal Calcium Response to Hypoxia in Naked Mole-Rat Hippocampus
|
|---|---|
| Published in |
PLOS ONE, February 2012
|
| DOI | 10.1371/journal.pone.0031568 |
| Pubmed ID | |
| Authors |
Bethany L. Peterson, John Larson, Rochelle Buffenstein, Thomas J. Park, Christopher P. Fall |
| Abstract |
Naked mole-rats are highly social and strictly subterranean rodents that live in large communal colonies in sealed and chronically oxygen-depleted burrows. Brain slices from naked mole-rats show extreme tolerance to hypoxia compared to slices from other mammals, as indicated by maintenance of synaptic transmission under more hypoxic conditions and three fold longer latency to anoxic depolarization. A key factor in determining whether or not the cellular response to hypoxia is reversible or leads to cell death may be the elevation of intracellular calcium concentration. In the present study, we used fluorescent imaging techniques to measure relative intracellular calcium changes in CA1 pyramidal cells of hippocampal slices during hypoxia. We found that calcium accumulation during hypoxia was significantly and substantially attenuated in slices from naked mole-rats compared to slices from laboratory mice. This was the case for both neonatal (postnatal day 6) and older (postnatal day 20) age groups. Furthermore, while both species demonstrated more calcium accumulation at older ages, the older naked mole-rats showed a smaller calcium accumulation response than even the younger mice. A blunted intracellular calcium response to hypoxia may contribute to the extreme hypoxia tolerance of naked mole-rat neurons. The results are discussed in terms of a general hypothesis that a very prolonged or arrested developmental process may allow adult naked mole-rat brain to retain the hypoxia tolerance normally only seen in neonatal mammals. |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 3% |
| Unknown | 77 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 18 | 23% |
| Student > Ph. D. Student | 15 | 19% |
| Researcher | 12 | 15% |
| Student > Master | 7 | 9% |
| Student > Doctoral Student | 5 | 6% |
| Other | 5 | 6% |
| Unknown | 17 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 26 | 33% |
| Biochemistry, Genetics and Molecular Biology | 13 | 16% |
| Neuroscience | 7 | 9% |
| Medicine and Dentistry | 7 | 9% |
| Nursing and Health Professions | 2 | 3% |
| Other | 4 | 5% |
| Unknown | 20 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2012.
All research outputs
#2,418,209
of 22,709,015 outputs
Outputs from PLOS ONE
#30,970
of 193,901 outputs
Outputs of similar age
#15,070
of 156,366 outputs
Outputs of similar age from PLOS ONE
#488
of 3,530 outputs
Altmetric has tracked 22,709,015 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 193,901 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 156,366 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 3,530 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.