| Chapter title |
Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics
|
|---|---|
| Chapter number | 5003 |
| Book title |
Translational Neuropsychopharmacology
|
| Published in |
Current topics in behavioral neurosciences, June 2016
|
| DOI | 10.1007/7854_2015_5003 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-933911-5, 978-3-31-933913-9
|
| Authors |
Kazdoba, Tatiana M, Leach, Prescott T, Yang, Mu, Silverman, Jill L, Solomon, Marjorie, Crawley, Jacqueline N, Tatiana M. Kazdoba, Prescott T. Leach, Mu Yang, Jill L. Silverman, Marjorie Solomon, Jacqueline N. Crawley |
| Editors |
Trevor W. Robbins, Barbara J. Sahakian |
| Abstract |
Animal models provide preclinical tools to investigate the causal role of genetic mutations and environmental factors in the etiology of autism spectrum disorder (ASD). Knockout and humanized knock-in mice, and more recently knockout rats, have been generated for many of the de novo single gene mutations and copy number variants (CNVs) detected in ASD and comorbid neurodevelopmental disorders. Mouse models incorporating genetic and environmental manipulations have been employed for preclinical testing of hypothesis-driven pharmacological targets, to begin to develop treatments for the diagnostic and associated symptoms of autism. In this review, we summarize rodent behavioral assays relevant to the core features of autism, preclinical and clinical evaluations of pharmacological interventions, and strategies to improve the translational value of rodent models of autism. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 255 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 15% |
| Student > Master | 38 | 15% |
| Student > Bachelor | 36 | 14% |
| Researcher | 35 | 14% |
| Professor > Associate Professor | 11 | 4% |
| Other | 33 | 13% |
| Unknown | 64 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 62 | 24% |
| Agricultural and Biological Sciences | 32 | 13% |
| Biochemistry, Genetics and Molecular Biology | 26 | 10% |
| Psychology | 21 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 4% |
| Other | 29 | 11% |
| Unknown | 74 | 29% |