↓ Skip to main content

Alterations in the endocannabinoid system in the rat valproic acid model of autism

Overview of attention for article published in Behavioural Brain Research, July 2013
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

twitter
6 tweeters
facebook
3 Facebook pages
wikipedia
1 Wikipedia page

Citations

dimensions_citation
100 Dimensions

Readers on

mendeley
147 Mendeley
citeulike
1 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Alterations in the endocannabinoid system in the rat valproic acid model of autism
Published in
Behavioural Brain Research, July 2013
DOI 10.1016/j.bbr.2013.04.043
Pubmed ID
Authors

D.M. Kerr, L. Downey, M. Conboy, D.P. Finn, M. Roche

Abstract

The endocannabinoid system plays a crucial role in regulating emotionality and social behaviour, however it is unknown whether this system plays a role in symptoms associated with autism spectrum disorders. The current study evaluated if alterations in the endocannabinoid system accompany behavioural changes in the valproic acid (VPA) rat model of autism. Adolescent rats prenatally exposed to VPA exhibited impaired social investigatory behaviour, hypoalgesia and reduced lococmotor activity on exposure to a novel aversive arena. Levels of the endocananbinoids, anandamide (AEA) and 2-arachidonylglycerol (2-AG) in the hippocampus, frontal cortex or cerebellum were not altered in VPA- versus saline-exposed animals. However, the expression of mRNA for diacylglycerol lipase α, the enzyme primarily responsible for the synthesis of 2-AG, was reduced in the cerebellum of VPA-exposed rats. Furthermore, while the expression of mRNA for the 2-AG-catabolising enzyme monoacylglycerol lipase was reduced, the activity of this enzyme was increased, in the hippocampus of VPA-exposed animals. CB1 or CB2 receptor expression was not altered in any of the regions examined, however VPA-exposed rats exhibited reduced PPARα and GPR55 expression in the frontal cortex and PPARγ and GPR55 expression in the hippocampus, additional receptor targets of the endocannabinoids. Furthermore, tissue levels of the fatty acid amide hydrolase substrates, AEA, oleoylethanolamide and palmitoylethanolamide, were higher in the hippocampus of VPA-exposed rats immediately following social exposure. These data indicate that prenatal VPA exposure is associated with alterations in the brain's endocannabinoid system and support the hypothesis that endocannabinoid dysfunction may underlie behavioural abnormalities observed in autism spectrum disorders.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 2 1%
Hong Kong 1 <1%
France 1 <1%
Ireland 1 <1%
Germany 1 <1%
Brazil 1 <1%
United Kingdom 1 <1%
Korea, Republic of 1 <1%
United States 1 <1%
Other 0 0%
Unknown 137 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 16%
Student > Bachelor 20 14%
Researcher 17 12%
Student > Master 16 11%
Student > Doctoral Student 14 10%
Other 40 27%
Unknown 16 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 38 26%
Neuroscience 34 23%
Medicine and Dentistry 17 12%
Psychology 11 7%
Biochemistry, Genetics and Molecular Biology 7 5%
Other 18 12%
Unknown 22 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 December 2016.
All research outputs
#3,406,414
of 19,096,926 outputs
Outputs from Behavioural Brain Research
#741
of 4,380 outputs
Outputs of similar age
#29,953
of 167,357 outputs
Outputs of similar age from Behavioural Brain Research
#10
of 68 outputs
Altmetric has tracked 19,096,926 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,380 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 167,357 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.