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X Demographics
Mendeley readers
Attention Score in Context
| Title |
G protein-coupled receptors as targets for transformative neuropsychiatric therapeutics
|
|---|---|
| Published in |
American Journal of Physiology: Cell Physiology, April 2023
|
| DOI | 10.1152/ajpcell.00397.2022 |
| Pubmed ID | |
| Authors |
Gavin P Schmitz, Bryan L Roth |
| Abstract |
G protein coupled receptors (GPCRs) constitute the largest family of druggable genes in the human genome. Even though perhaps 30% of approved medications target GPCRs, they interact with only a small number of them. Here we consider whether there might be new opportunities for transformative therapeutics for neuropsychiatric disorders by specifically targeting both known and understudied GPCRs. Using psychedelic drugs which target serotonin receptors as an example, we show how recent insights into the structure, function, signaling, and cell biology of these receptors has led to potentially novel therapeutics. We next focus on the possibility that non-psychedelic 5-HT2A agonists might prove to be safe and rapidly acting antidepressants. Finally, we examine understudied and orphan GPCRs using the MRGPR-family of receptors as an example. |
X Demographics
The data shown below were collected from the profiles of 31 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 32% |
| Belgium | 1 | 3% |
| Netherlands | 1 | 3% |
| Unknown | 19 | 61% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 20 | 65% |
| Scientists | 9 | 29% |
| Science communicators (journalists, bloggers, editors) | 2 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 2 | 29% |
| Student > Bachelor | 1 | 14% |
| Unspecified | 1 | 14% |
| Unknown | 3 | 43% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 2 | 29% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 14% |
| Unspecified | 1 | 14% |
| Unknown | 3 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2023.
All research outputs
#2,139,285
of 25,410,626 outputs
Outputs from American Journal of Physiology: Cell Physiology
#145
of 2,766 outputs
Outputs of similar age
#42,084
of 413,978 outputs
Outputs of similar age from American Journal of Physiology: Cell Physiology
#5
of 46 outputs
Altmetric has tracked 25,410,626 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,766 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 413,978 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.