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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A Chlamydomonas-Derived Human Papillomavirus 16 E7 Vaccine Induces Specific Tumor Protection
|
|---|---|
| Published in |
PLOS ONE, April 2013
|
| DOI | 10.1371/journal.pone.0061473 |
| Pubmed ID | |
| Authors |
Olivia C. Demurtas, Silvia Massa, Paola Ferrante, Aldo Venuti, Rosella Franconi, Giovanni Giuliano |
| Abstract |
The E7 protein of the Human Papillomavirus (HPV) type 16, being involved in malignant cellular transformation, represents a key antigen for developing therapeutic vaccines against HPV-related lesions and cancers. Recombinant production of this vaccine antigen in an active form and in compliance with good manufacturing practices (GMP) plays a crucial role for developing effective vaccines. E7-based therapeutic vaccines produced in plants have been shown to be active in tumor regression and protection in pre-clinical models. However, some drawbacks of in whole-plant vaccine production encouraged us to explore the production of the E7-based therapeutic vaccine in Chlamydomonas reinhardtii, an organism easy to grow and transform and fully amenable to GMP guidelines. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Denmark | 1 | <1% |
| Italy | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 145 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 17% |
| Student > Master | 26 | 17% |
| Student > Bachelor | 25 | 17% |
| Student > Ph. D. Student | 24 | 16% |
| Student > Doctoral Student | 8 | 5% |
| Other | 18 | 12% |
| Unknown | 22 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 51 | 34% |
| Biochemistry, Genetics and Molecular Biology | 47 | 32% |
| Immunology and Microbiology | 6 | 4% |
| Medicine and Dentistry | 6 | 4% |
| Engineering | 5 | 3% |
| Other | 8 | 5% |
| Unknown | 26 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2020.
All research outputs
#6,392,214
of 22,710,079 outputs
Outputs from PLOS ONE
#76,682
of 193,906 outputs
Outputs of similar age
#53,797
of 195,120 outputs
Outputs of similar age from PLOS ONE
#1,555
of 4,967 outputs
Altmetric has tracked 22,710,079 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 193,906 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,120 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 4,967 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.