Title |
The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice
|
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Published in |
Alzheimer's Research & Therapy, May 2013
|
DOI | 10.1186/alzrt179 |
Pubmed ID | |
Authors |
Marguerite Prior, Richard Dargusch, Jennifer L Ehren, Chandramouli Chiruta, David Schubert |
Abstract |
Despite years of research, there are no disease-modifying drugs for Alzheimer's disease (AD), a fatal, age-related neurodegenerative disorder. Screening for potential therapeutics in rodent models of AD has generally relied on testing compounds before pathology is present, thereby modeling disease prevention rather than disease modification. Furthermore, this approach to screening does not reflect the clinical presentation of AD patients which could explain the failure to translate compounds identified as beneficial in animal models to disease modifying compounds in clinical trials. Clearly a better approach to pre-clinical drug screening for AD is required. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 11% |
Canada | 2 | 7% |
Spain | 2 | 7% |
France | 2 | 7% |
United States | 2 | 7% |
Italy | 1 | 4% |
Finland | 1 | 4% |
Papua New Guinea | 1 | 4% |
Unknown | 14 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 22 | 79% |
Practitioners (doctors, other healthcare professionals) | 3 | 11% |
Scientists | 2 | 7% |
Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
United Kingdom | 1 | <1% |
Unknown | 122 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 30 | 24% |
Student > Master | 21 | 17% |
Student > Ph. D. Student | 14 | 11% |
Student > Bachelor | 11 | 9% |
Other | 11 | 9% |
Other | 17 | 14% |
Unknown | 21 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 23 | 18% |
Medicine and Dentistry | 21 | 17% |
Biochemistry, Genetics and Molecular Biology | 16 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 15 | 12% |
Neuroscience | 8 | 6% |
Other | 15 | 12% |
Unknown | 27 | 22% |