Title |
Specific Metabolomics Adaptations Define a Differential Regional Vulnerability in the Adult Human Cerebral Cortex
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Published in |
Frontiers in Molecular Neuroscience, December 2016
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DOI | 10.3389/fnmol.2016.00138 |
Pubmed ID | |
Authors |
Rosanna Cabré, Mariona Jové, Alba Naudí, Victoria Ayala, Gerard Piñol-Ripoll, Maria P. Gil-Villar, Mayelin Dominguez-Gonzalez, Èlia Obis, Rebeca Berdun, Natalia Mota-Martorell, Manuel Portero-Otin, Isidre Ferrer, Reinald Pamplona |
Abstract |
Brain neurons offer diverse responses to stresses and detrimental factors during development and aging, and as a result of both neurodegenerative and neuropsychiatric disorders. This multiplicity of responses can be ascribed to the great diversity among neuronal populations. Here we have determined the metabolomic profile of three healthy adult human brain regions-entorhinal cortex, hippocampus, and frontal cortex-using mass spectrometry-based technologies. Our results show the existence of a lessened energy demand, mitochondrial stress, and lower one-carbon metabolism (particularly restricted to the methionine cycle) specifically in frontal cortex. These findings, along with the better antioxidant capacity and lower mTOR signaling also seen in frontal cortex, suggest that this brain region is especially resistant to stress compared to the entorhinal cortex and hippocampus, which are more vulnerable regions. Globally, our results show the presence of specific metabolomics adaptations in three mature, healthy human brain regions, confirming the existence of cross-regional differences in cell vulnerability in the human cerebral cortex. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 33% |
Switzerland | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 39 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 18% |
Student > Master | 6 | 15% |
Researcher | 3 | 8% |
Professor > Associate Professor | 3 | 8% |
Student > Postgraduate | 2 | 5% |
Other | 5 | 13% |
Unknown | 13 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 9 | 23% |
Biochemistry, Genetics and Molecular Biology | 6 | 15% |
Medicine and Dentistry | 4 | 10% |
Immunology and Microbiology | 2 | 5% |
Neuroscience | 2 | 5% |
Other | 1 | 3% |
Unknown | 15 | 38% |