[Clozapine-induced cholestatic jaundice: a case report].
Zeitschrift für Gastroenterologie, July 1989
Dorta, G, Siebenmann, R, Fröhli, P, Freytag, P, Koelz, H R
We report on a patient who became jaundiced during treatment with clozapine (Leponex). Histologically, cholestatic hepatitis with single-cell necroses of hepatocytes and infiltration of the portal zones with eosinophilic granulocytes were found. The patient recovered after discontinuation of clozapine, and liver function tests returned to normal within 4 weeks. This adverse effect of clozapine suggests that this "atypical" tricyclic neuroleptic resembles the phenothiazines both with regard to therapeutic spectrum and side effects.
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