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Mutations in NA That Induced Low pH-Stability and Enhanced the Replication of Pandemic (H1N1) 2009 Influenza A Virus at an Early Stage of the Pandemic

Overview of attention for article published in PLOS ONE, May 2013
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Title
Mutations in NA That Induced Low pH-Stability and Enhanced the Replication of Pandemic (H1N1) 2009 Influenza A Virus at an Early Stage of the Pandemic
Published in
PLOS ONE, May 2013
DOI 10.1371/journal.pone.0064439
Pubmed ID
Authors

Tadanobu Takahashi, Jiasheng Song, Takashi Suzuki, Yoshihiro Kawaoka

Abstract

An influenza A virus that originated in pigs caused a pandemic in 2009. The sialidase activity of the neuraminidase (NA) of previous pandemic influenza A viruses are stable at low pH (≤5). Here, we identified the amino acids responsible for this property. We found differences in low-pH stability at pH 5.0 among pandemic (H1N1) 2009 viruses, which enhanced the replication of these viruses. Low-pH-stable NA enhancement of virus replication may have contributed to the rapid worldwide spread and adaptation to humans of pandemic (H1N1) 2009 viruses during the early stages of the 2009 pandemic.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 36 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 24%
Student > Bachelor 7 19%
Student > Master 7 19%
Student > Ph. D. Student 7 19%
Student > Doctoral Student 1 3%
Other 3 8%
Unknown 3 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 27%
Biochemistry, Genetics and Molecular Biology 6 16%
Veterinary Science and Veterinary Medicine 4 11%
Immunology and Microbiology 3 8%
Medicine and Dentistry 3 8%
Other 6 16%
Unknown 5 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2013.
All research outputs
#18,338,946
of 22,710,079 outputs
Outputs from PLOS ONE
#154,147
of 193,906 outputs
Outputs of similar age
#146,778
of 195,184 outputs
Outputs of similar age from PLOS ONE
#3,760
of 4,999 outputs
Altmetric has tracked 22,710,079 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,906 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,184 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,999 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.