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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Intrinsic Photosensitivity Enhances Motility of T Lymphocytes
|
|---|---|
| Published in |
Scientific Reports, December 2016
|
| DOI | 10.1038/srep39479 |
| Pubmed ID | |
| Authors |
Thieu X. Phan, Barbara Jaruga, Sandeep C. Pingle, Bidhan C. Bandyopadhyay, Gerard P. Ahern |
| Abstract |
Sunlight has important biological effects in human skin. Ultraviolet (UV) light striking the epidermis catalyzes the synthesis of Vitamin D and triggers melanin production. Although a causative element in skin cancers, sunlight is also associated with positive health outcomes including reduced incidences of autoimmune diseases and cancers. The mechanisms, however, by which light affects immune function remain unclear. Here we describe direct photon sensing in human and mouse T lymphocytes, a cell-type highly abundant in skin. Blue light irradiation at low doses (<300 mJ cm(-2)) triggers synthesis of hydrogen peroxide (H2O2) in T cells revealed by the genetically encoded reporter HyPerRed. In turn, H2O2 activates a Src kinase/phospholipase C-γ1 (PLC-γ1) signaling pathway and Ca(2+) mobilization. Pharmacologic inhibition or genetic disruption of Lck kinase, PLC-γ1 or the T cell receptor complex inhibits light-evoked Ca(2+) transients. Notably, both light and H2O2 enhance T-cell motility in a Lck-dependent manner. Thus, T lymphocytes possess intrinsic photosensitivity and this property may enhance their motility in skin. |
X Demographics
The data shown below were collected from the profiles of 365 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 36 | 10% |
| United States | 33 | 9% |
| Turkey | 17 | 5% |
| Argentina | 13 | 4% |
| Malaysia | 10 | 3% |
| United Kingdom | 9 | 2% |
| France | 7 | 2% |
| Chile | 5 | 1% |
| Canada | 5 | 1% |
| Other | 42 | 12% |
| Unknown | 188 | 52% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 308 | 84% |
| Practitioners (doctors, other healthcare professionals) | 27 | 7% |
| Scientists | 23 | 6% |
| Science communicators (journalists, bloggers, editors) | 5 | 1% |
| Unknown | 2 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 1% |
| Slovenia | 1 | 1% |
| Unknown | 81 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 13% |
| Student > Master | 10 | 12% |
| Researcher | 9 | 11% |
| Student > Bachelor | 8 | 10% |
| Other | 7 | 8% |
| Other | 18 | 22% |
| Unknown | 20 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 22% |
| Agricultural and Biological Sciences | 12 | 14% |
| Biochemistry, Genetics and Molecular Biology | 11 | 13% |
| Immunology and Microbiology | 4 | 5% |
| Nursing and Health Professions | 4 | 5% |
| Other | 7 | 8% |
| Unknown | 27 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 727. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 January 2024.
All research outputs
#28,326
of 25,768,270 outputs
Outputs from Scientific Reports
#444
of 142,915 outputs
Outputs of similar age
#563
of 425,314 outputs
Outputs of similar age from Scientific Reports
#14
of 3,748 outputs
Altmetric has tracked 25,768,270 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 142,915 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 425,314 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 3,748 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.