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Intrinsic Photosensitivity Enhances Motility of T Lymphocytes

Overview of attention for article published in Scientific Reports, December 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

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mendeley
43 Mendeley
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1 CiteULike
Title
Intrinsic Photosensitivity Enhances Motility of T Lymphocytes
Published in
Scientific Reports, December 2016
DOI 10.1038/srep39479
Pubmed ID
Authors

Thieu X. Phan, Barbara Jaruga, Sandeep C. Pingle, Bidhan C. Bandyopadhyay, Gerard P. Ahern

Abstract

Sunlight has important biological effects in human skin. Ultraviolet (UV) light striking the epidermis catalyzes the synthesis of Vitamin D and triggers melanin production. Although a causative element in skin cancers, sunlight is also associated with positive health outcomes including reduced incidences of autoimmune diseases and cancers. The mechanisms, however, by which light affects immune function remain unclear. Here we describe direct photon sensing in human and mouse T lymphocytes, a cell-type highly abundant in skin. Blue light irradiation at low doses (<300 mJ cm(-2)) triggers synthesis of hydrogen peroxide (H2O2) in T cells revealed by the genetically encoded reporter HyPerRed. In turn, H2O2 activates a Src kinase/phospholipase C-γ1 (PLC-γ1) signaling pathway and Ca(2+) mobilization. Pharmacologic inhibition or genetic disruption of Lck kinase, PLC-γ1 or the T cell receptor complex inhibits light-evoked Ca(2+) transients. Notably, both light and H2O2 enhance T-cell motility in a Lck-dependent manner. Thus, T lymphocytes possess intrinsic photosensitivity and this property may enhance their motility in skin.

Twitter Demographics

The data shown below were collected from the profiles of 145 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 2 5%
Russia 1 2%
Slovenia 1 2%
Unknown 39 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 21%
Researcher 9 21%
Unspecified 5 12%
Student > Master 4 9%
Other 3 7%
Other 13 30%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 26%
Medicine and Dentistry 9 21%
Unspecified 8 19%
Biochemistry, Genetics and Molecular Biology 5 12%
Immunology and Microbiology 2 5%
Other 8 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 566. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2019.
All research outputs
#12,475
of 13,388,233 outputs
Outputs from Scientific Reports
#207
of 64,839 outputs
Outputs of similar age
#780
of 370,615 outputs
Outputs of similar age from Scientific Reports
#14
of 4,921 outputs
Altmetric has tracked 13,388,233 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 64,839 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 370,615 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 4,921 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.