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Twitter Demographics
Mendeley readers
Attention Score in Context
| Title |
Immune mechanisms underlying COVID-19 pathology and post-acute sequelae of SARS-CoV-2 infection (PASC)
|
|---|---|
| Published in |
eLife, May 2023
|
| DOI | 10.7554/elife.86014 |
| Pubmed ID | |
| Authors |
Sindhu Mohandas, Prasanna Jagannathan, Timothy J Henrich, Zaki A Sherif, Christian Bime, Erin Quinlan, Michael A Portman, Marila Gennaro, Jalees Rehman |
| Abstract |
With a global tally of more than 500 million cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections to date, there are growing concerns about the post-acute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID. Recent studies suggest that exaggerated immune responses are key determinants of the severity and outcomes of the initial SARS-CoV-2 infection as well as subsequent PASC. The complexity of the innate and adaptive immune responses in the acute and post-acute period requires in-depth mechanistic analyses to identify specific molecular signals as well as specific immune cell populations which promote PASC pathogenesis. In this review, we examine the current literature on mechanisms of immune dysregulation in severe COVID-19 and the limited emerging data on the immunopathology of PASC. While the acute and post-acute phases may share some parallel mechanisms of immunopathology, it is likely that PASC immunopathology is quite distinct and heterogeneous, thus requiring large-scale longitudinal analyses in patients with and without PASC after an acute SARS-CoV-2 infection. By outlining the knowledge gaps in the immunopathology of PASC, we hope to provide avenues for novel research directions that will ultimately lead to precision therapies which restore healthy immune function in PASC patients. |
Twitter Demographics
The data shown below were collected from the profiles of 543 tweeters who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 65 | 12% |
| Canada | 28 | 5% |
| United Kingdom | 23 | 4% |
| Germany | 15 | 3% |
| Mexico | 12 | 2% |
| Australia | 12 | 2% |
| Spain | 10 | 2% |
| Japan | 7 | 1% |
| France | 7 | 1% |
| Other | 51 | 9% |
| Unknown | 313 | 58% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 442 | 81% |
| Scientists | 58 | 11% |
| Practitioners (doctors, other healthcare professionals) | 33 | 6% |
| Science communicators (journalists, bloggers, editors) | 10 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 14% |
| Researcher | 2 | 9% |
| Professor | 1 | 5% |
| Other | 1 | 5% |
| Student > Master | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 13 | 59% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 27% |
| Biochemistry, Genetics and Molecular Biology | 1 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
| Immunology and Microbiology | 1 | 5% |
| Nursing and Health Professions | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 12 | 55% |
Attention Score in Context
This research output has an Altmetric Attention Score of 221. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2023.
All research outputs
#164,181
of 24,508,104 outputs
Outputs from eLife
#357
of 14,974 outputs
Outputs of similar age
#3,827
of 369,136 outputs
Outputs of similar age from eLife
#15
of 423 outputs
Altmetric has tracked 24,508,104 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,974 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 36.7. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,136 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 423 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.