Chapter title |
Structured Sparse Low-Rank Regression Model for Brain-Wide and Genome-Wide Associations
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Chapter number | 40 |
Book title |
Medical Image Computing and Computer-Assisted Intervention – MICCAI 2016
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Published in |
Lecture notes in computer science, October 2016
|
DOI | 10.1007/978-3-319-46720-7_40 |
Pubmed ID | |
Book ISBNs |
978-3-31-946719-1, 978-3-31-946720-7, 978-3-31-946719-1, 978-3-31-946720-7
|
Authors |
Xiaofeng Zhu, Heung-Il Suk, Heng Huang, Dinggang Shen, Xiaofeng Zhu, Heung-Il Suk, Heng Huang, Dinggang Shen |
Editors |
Sebastien Ourselin, Leo Joskowicz, Mert R. Sabuncu, Gozde Unal, William Wells |
Abstract |
With the advances of neuroimaging techniques and genome sequences understanding, the phenotype and genotype data have been utilized to study the brain diseases (known as imaging genetics). One of the most important topics in image genetics is to discover the genetic basis of phenotypic markers and their associations. In such studies, the linear regression models have been playing an important role by providing interpretable results. However, due to their modeling characteristics, it is limited to effectively utilize inherent information among the phenotypes and genotypes, which are helpful for better understanding their associations. In this work, we propose a structured sparse low-rank regression method to explicitly consider the correlations within the imaging phenotypes and the genotypes simultaneously for Brain-Wide and Genome-Wide Association (BW-GWA) study. Specifically, we impose the low-rank constraint as well as the structured sparse constraint on both phenotypes and phenotypes. By using the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset, we conducted experiments of predicting the phenotype data from genotype data and achieved performance improvement by 12.75 % on average in terms of the root-mean-square error over the state-of-the-art methods. |
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Researcher | 6 | 33% |
Student > Ph. D. Student | 5 | 28% |
Student > Bachelor | 2 | 11% |
Lecturer | 1 | 6% |
Professor > Associate Professor | 1 | 6% |
Other | 0 | 0% |
Unknown | 3 | 17% |
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Computer Science | 3 | 17% |
Medicine and Dentistry | 3 | 17% |
Biochemistry, Genetics and Molecular Biology | 1 | 6% |
Psychology | 1 | 6% |
Other | 0 | 0% |
Unknown | 6 | 33% |