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Mendeley readers
Attention Score in Context
| Title |
Regioselective monodeprotection of peracetylated carbohydrates
|
|---|---|
| Published in |
Nature Protocols, September 2012
|
| DOI | 10.1038/nprot.2012.098 |
| Pubmed ID | |
| Authors |
Marco Filice, Jose M Guisan, Marco Terreni, Jose M Palomo |
| Abstract |
This protocol describes the regioselective deprotection of single hydroxyls in peracetylated monosaccharides and disaccharides by enzymatic or chemoenzymatic strategies. The introduction of a one-pot enzymatic step by using immobilized biocatalysts obviates the requirement to carry out tedious workups and time-consuming purifications. By using this straightforward protocol, different per-O-acetylated glycopyranosides (mono- or disaccharides, 1-substituted or glycals) can be transformed into a whole set of differentially monodeprotected 1-alcohols, 3-alcohols, 4-alcohols and 6-alcohols in high yields. These tailor-made glycosyl acceptors can then be used for stereoselective glycosylation for oligosaccharide and glycoderivative synthesis. They have been successfully used as building blocks to synthesize tailor-made di- and trisaccharides involved in the structure of lacto-N-neo-tetraose and precursors of the tumor-associated carbohydrate antigen T and the antitumoral drug peracetylated β-naphtyl-lactosamine. We are able to prepare a purified monoprotected carbohydrate in between 1 and 4 d. With this protocol, the small library of monodeprotected products can be synthesized in 1-2 weeks. |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 62 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 21% |
| Student > Master | 11 | 18% |
| Researcher | 9 | 15% |
| Student > Doctoral Student | 7 | 11% |
| Student > Bachelor | 6 | 10% |
| Other | 5 | 8% |
| Unknown | 11 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 38 | 61% |
| Agricultural and Biological Sciences | 4 | 6% |
| Biochemistry, Genetics and Molecular Biology | 3 | 5% |
| Unspecified | 1 | 2% |
| Chemical Engineering | 1 | 2% |
| Other | 2 | 3% |
| Unknown | 13 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2015.
All research outputs
#7,185,319
of 22,711,242 outputs
Outputs from Nature Protocols
#1,943
of 2,730 outputs
Outputs of similar age
#53,685
of 169,181 outputs
Outputs of similar age from Nature Protocols
#22
of 31 outputs
Altmetric has tracked 22,711,242 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 2,730 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 169,181 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.