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Endogenous phospholipase A2 inhibitors in snakes: a brief overview

Overview of attention for article published in Journal of Venomous Animals and Toxins including Tropical Diseases, December 2016
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Citations

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19 Dimensions

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38 Mendeley
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Title
Endogenous phospholipase A2 inhibitors in snakes: a brief overview
Published in
Journal of Venomous Animals and Toxins including Tropical Diseases, December 2016
DOI 10.1186/s40409-016-0092-5
Pubmed ID
Authors

Patrícia Cota Campos, Lutiana Amaral de Melo, Gabriel Latorre Fortes Dias, Consuelo Latorre Fortes-Dias

Abstract

The blood plasma of numerous snake species naturally comprises endogenous phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may eventually reach their circulation. This inhibitor type is generally known as snake blood phospholipase A2 inhibitors (sbPLIs). Most, if not all sbPLIs are oligomeric glycosylated proteins, although the carbohydrate moiety may not be essential for PLA2 inhibition in every case. The presently known sbPLIs belong to one of three structural classes - namely sbαPLI, sbβPLI or sbγPLI - depending on the presence of characteristic C-type lectin-like domains, leucine-rich repeats or three-finger motifs, respectively. Currently, the most numerous inhibitors described in the literature are sbαPLIs and sbγPLIs, whereas sbβPLIs are rare. When the target PLA2 is a Lys49 homolog or an Asp49 myotoxin, the sbPLI is denominated a myotoxin inhibitor protein (MIP). In this brief overview, the most relevant data on sbPLIs will be presented. Representative examples of sbαPLIs and sbγPLIs from two Old World - Gloydius brevicaudus and Malayopython reticulatus - and two New World - Bothrops alternatus and Crotalus durissus terrificus - snake species will be emphasized.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 24%
Student > Master 6 16%
Student > Ph. D. Student 4 11%
Researcher 4 11%
Other 2 5%
Other 4 11%
Unknown 9 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 32%
Agricultural and Biological Sciences 8 21%
Chemistry 2 5%
Arts and Humanities 2 5%
Veterinary Science and Veterinary Medicine 1 3%
Other 3 8%
Unknown 10 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2020.
All research outputs
#11,146,072
of 17,795,994 outputs
Outputs from Journal of Venomous Animals and Toxins including Tropical Diseases
#222
of 430 outputs
Outputs of similar age
#212,341
of 394,621 outputs
Outputs of similar age from Journal of Venomous Animals and Toxins including Tropical Diseases
#19
of 30 outputs
Altmetric has tracked 17,795,994 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 430 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 394,621 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.