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BB0172, a Borrelia burgdorferi Outer Membrane Protein That Binds Integrin α3β1

Overview of attention for article published in Journal of Bacteriology, May 2013
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Title
BB0172, a Borrelia burgdorferi Outer Membrane Protein That Binds Integrin α3β1
Published in
Journal of Bacteriology, May 2013
DOI 10.1128/jb.00187-13
Pubmed ID
Authors

Elaine Wood, Silvia Tamborero, Ismael Mingarro, Maria D. Esteve-Gassent

Abstract

Lyme disease is a multisystemic disorder caused by Borrelia burgdorferi infection. Upon infection, some B. burgdorferi genes are upregulated, including members of the microbial surface components recognizing adhesive matrix molecule (MSCRAMM) protein family, which facilitate B. burgdorferi adherence to extracellular matrix components of the host. Comparative genome analysis has revealed a new family of B. burgdorferi proteins containing the von Willebrand factor A (vWFA) domain. In the present study, we characterized the expression and membrane association of the vWFA domain-containing protein BB0172 by using in vitro transcription/translation systems in the presence of microsomal membranes and with detergent phase separation assays. Our results showed evidence of BB0172 localization in the outer membrane, the orientation of the vWFA domain to the extracellular environment, and its function as a metal ion-dependent integrin-binding protein. This is the first report of a borrelial adhesin with a metal ion-dependent adhesion site (MIDAS) motif that is similar to those observed in eukaryotic integrins and has a similar function.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 2 4%
United States 1 2%
Poland 1 2%
Unknown 41 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 18%
Researcher 6 13%
Unspecified 5 11%
Student > Doctoral Student 3 7%
Student > Bachelor 3 7%
Other 10 22%
Unknown 10 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 20%
Biochemistry, Genetics and Molecular Biology 7 16%
Immunology and Microbiology 6 13%
Unspecified 5 11%
Medicine and Dentistry 4 9%
Other 4 9%
Unknown 10 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2013.
All research outputs
#14,914,476
of 25,374,647 outputs
Outputs from Journal of Bacteriology
#14,775
of 16,901 outputs
Outputs of similar age
#111,997
of 208,729 outputs
Outputs of similar age from Journal of Bacteriology
#32
of 55 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 16,901 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,729 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.