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BB0172, a Borrelia burgdorferi Outer Membrane Protein That Binds Integrin α 3 β 1

Overview of attention for article published in Journal of Bacteriology, August 2013
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (59th percentile)

Mentioned by

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1 tweeter
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5 Facebook pages

Citations

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15 Dimensions

Readers on

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36 Mendeley
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Title
BB0172, a Borrelia burgdorferi Outer Membrane Protein That Binds Integrin α 3 β 1
Published in
Journal of Bacteriology, August 2013
DOI 10.1128/jb.00187-13
Pubmed ID
Authors

Elaine Wood, Silvia Tamborero, Ismael Mingarro, Maria D. Esteve-Gassent

Abstract

Lyme disease is a multisystemic disorder caused by Borrelia burgdorferi infection. Upon infection, some B. burgdorferi genes are upregulated, including members of the microbial surface components recognizing adhesive matrix molecule (MSCRAMM) protein family, which facilitate B. burgdorferi adherence to extracellular matrix components of the host. Comparative genome analysis has revealed a new family of B. burgdorferi proteins containing the von Willebrand factor A (vWFA) domain. In the present study, we characterized the expression and membrane association of the vWFA domain-containing protein BB0172 by using in vitro transcription/translation systems in the presence of microsomal membranes and with detergent phase separation assays. Our results showed evidence of BB0172 localization in the outer membrane, the orientation of the vWFA domain to the extracellular environment, and its function as a metal ion-dependent integrin-binding protein. This is the first report of a borrelial adhesin with a metal ion-dependent adhesion site (MIDAS) motif that is similar to those observed in eukaryotic integrins and has a similar function.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 2 6%
United States 1 3%
Poland 1 3%
Unknown 32 89%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 22%
Researcher 6 17%
Librarian 5 14%
Student > Bachelor 3 8%
Professor 3 8%
Other 6 17%
Unknown 5 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 25%
Biochemistry, Genetics and Molecular Biology 7 19%
Immunology and Microbiology 5 14%
Veterinary Science and Veterinary Medicine 4 11%
Medicine and Dentistry 4 11%
Other 2 6%
Unknown 5 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2013.
All research outputs
#9,912,052
of 17,888,394 outputs
Outputs from Journal of Bacteriology
#11,764
of 13,713 outputs
Outputs of similar age
#78,245
of 166,556 outputs
Outputs of similar age from Journal of Bacteriology
#30
of 71 outputs
Altmetric has tracked 17,888,394 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,713 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 166,556 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.