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Simultaneous Top-down Modulation of the Primary Somatosensory Cortex and Thalamic Nuclei during Active Tactile Discrimination

Overview of attention for article published in Journal of Neuroscience, February 2013
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Title
Simultaneous Top-down Modulation of the Primary Somatosensory Cortex and Thalamic Nuclei during Active Tactile Discrimination
Published in
Journal of Neuroscience, February 2013
DOI 10.1523/jneurosci.1659-12.2013
Pubmed ID
Authors

Miguel Pais-Vieira, Mikhail A. Lebedev, Michael C. Wiest, Miguel A. L. Nicolelis, Pais-Vieira M, Lebedev MA, Wiest MC, Nicolelis MA, M. Pais-Vieira, M. A. Lebedev, M. C. Wiest, M. A. L. Nicolelis

Abstract

The rat somatosensory system contains multiple thalamocortical loops (TCLs) that altogether process, in fundamentally different ways, tactile stimuli delivered passively or actively sampled. To elucidate potential top-down mechanisms that govern TCL processing in awake, behaving animals, we simultaneously recorded neuronal ensemble activity across multiple cortical and thalamic areas while rats performed an active aperture discrimination task. Single neurons located in the primary somatosensory cortex (S1), the ventroposterior medial, and the posterior medial thalamic nuclei of the trigeminal somatosensory pathways exhibited prominent anticipatory firing modulations before the whiskers touching the aperture edges. This cortical and thalamic anticipatory firing could not be explained by whisker movements or whisker stimulation, because neither trigeminal ganglion sensory-evoked responses nor EMG activity were detected during the same period. Both thalamic and S1 anticipatory activity were predictive of the animal's discrimination accuracy. Inactivation of the primary motor cortex (M1) with muscimol affected anticipatory patterns in S1 and the thalamus, and impaired the ability to predict the animal's performance accuracy based on thalamocortical anticipatory activity. These findings suggest that neural processing in TCLs is launched in anticipation of whisker contact with objects, depends on top-down effects generated in part by M1 activity, and cannot be explained by the classical feedforward model of the rat trigeminal system.

Mendeley readers

The data shown below were compiled from readership statistics for 211 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 8 4%
Germany 2 <1%
Netherlands 2 <1%
United Kingdom 2 <1%
Sweden 1 <1%
Switzerland 1 <1%
Australia 1 <1%
Israel 1 <1%
France 1 <1%
Other 3 1%
Unknown 189 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 61 29%
Researcher 61 29%
Student > Master 35 17%
Professor 10 5%
Student > Postgraduate 8 4%
Other 22 10%
Unknown 14 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 96 45%
Neuroscience 43 20%
Medicine and Dentistry 20 9%
Psychology 15 7%
Engineering 10 5%
Other 10 5%
Unknown 17 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2013.
All research outputs
#2,018,547
of 3,636,226 outputs
Outputs from Journal of Neuroscience
#4,977
of 9,099 outputs
Outputs of similar age
#44,700
of 85,837 outputs
Outputs of similar age from Journal of Neuroscience
#218
of 335 outputs
Altmetric has tracked 3,636,226 research outputs across all sources so far. This one is in the 26th percentile – i.e., 26% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,099 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 85,837 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 335 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.