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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells
|
|---|---|
| Published in |
BMC Cancer, May 2013
|
| DOI | 10.1186/1471-2407-13-252 |
| Pubmed ID | |
| Authors |
Hee-Sheung Lee, Nicholas CO Lee, Brenda R Grimes, Alexander Samoshkin, Artem V Kononenko, Ruchi Bansal, Hiroshi Masumoto, William C Earnshaw, Natalay Kouprina, Vladimir Larionov |
| Abstract |
Aneuploidy is a feature of most cancer cells that is often accompanied by an elevated rate of chromosome mis-segregation termed chromosome instability (CIN). While CIN can act as a driver of cancer genome evolution and tumor progression, recent findings point to the existence of a threshold level beyond which CIN becomes a barrier to tumor growth and therefore can be exploited therapeutically. Drugs known to increase CIN beyond the therapeutic threshold are currently few in number, and the clinical promise of targeting the CIN phenotype warrants new screening efforts. However, none of the existing methods, including the in vitro micronuclei (MNi) assay, developed to quantify CIN, is entirely satisfactory. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 17% |
| Mexico | 1 | 17% |
| United Kingdom | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 1 | 1% |
| Unknown | 88 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 26% |
| Researcher | 22 | 25% |
| Student > Master | 8 | 9% |
| Student > Bachelor | 7 | 8% |
| Student > Doctoral Student | 6 | 7% |
| Other | 13 | 15% |
| Unknown | 10 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 37% |
| Biochemistry, Genetics and Molecular Biology | 31 | 35% |
| Medicine and Dentistry | 8 | 9% |
| Chemistry | 2 | 2% |
| Immunology and Microbiology | 1 | 1% |
| Other | 1 | 1% |
| Unknown | 13 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2013.
All research outputs
#7,775,415
of 23,881,329 outputs
Outputs from BMC Cancer
#2,133
of 8,483 outputs
Outputs of similar age
#66,357
of 197,643 outputs
Outputs of similar age from BMC Cancer
#35
of 96 outputs
Altmetric has tracked 23,881,329 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 8,483 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,643 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 96 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.