Title |
Amorfrutin B is an efficient natural peroxisome proliferator-activated receptor gamma (PPARγ) agonist with potent glucose-lowering properties
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Published in |
Diabetologia, May 2013
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DOI | 10.1007/s00125-013-2920-2 |
Pubmed ID | |
Authors |
C. Weidner, S. J. Wowro, A. Freiwald, K. Kawamoto, A. Witzke, M. Kliem, K. Siems, L. Müller-Kuhrt, F. C. Schroeder, S. Sauer |
Abstract |
The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is an important gene regulator in glucose and lipid metabolism. Unfortunately, PPARγ-activating drugs of the thiazolidinedione class provoke adverse side effects. As recently shown, amorfrutin A1 is a natural glucose-lowering compound that selectively modulates PPARγ. In this study we aimed to characterise, in vitro, a large spectrum of the amorfrutins and similar molecules, which we isolated from various plants. We further studied in vivo the glucose-lowering effects of the so far undescribed amorfrutin B, which featured the most striking PPARγ-binding and pharmacological properties of this family of plant metabolites. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 4% |
Germany | 1 | 2% |
Unknown | 52 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 27% |
Student > Master | 7 | 13% |
Student > Bachelor | 5 | 9% |
Student > Ph. D. Student | 4 | 7% |
Student > Doctoral Student | 3 | 5% |
Other | 11 | 20% |
Unknown | 10 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 16 | 29% |
Biochemistry, Genetics and Molecular Biology | 9 | 16% |
Chemistry | 6 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 9% |
Unspecified | 3 | 5% |
Other | 5 | 9% |
Unknown | 11 | 20% |