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Nicotine promotes Mycobacterium tuberculosis H37Rv growth and overexpression of virulence genes

Overview of attention for article published in Microbiology and Immunology, June 2023
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)

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Title
Nicotine promotes Mycobacterium tuberculosis H37Rv growth and overexpression of virulence genes
Published in
Microbiology and Immunology, June 2023
DOI 10.1111/1348-0421.13085
Pubmed ID
Authors

Bruno Rivas‐Santiago, Jeny Haro‐Acosta, Adrian Rodríguez Carlos, Mariana H. Garcia‐Hernandez, Carmen J. Serrano, Irma Gonzalez‐Curiel, Cesar Rivas‐Santiago

Abstract

Tobacco consumption increases the susceptibility to develop infectious diseases such as tuberculosis (TB). Nicotine (Nc) is the main component of cigarette smoke with immunomodulatory properties, however, its effect on Mycobacterium tuberculosis (Mtb) has been scarcely investigated. The present study evaluated the effect of nicotine on the growth of Mtb and on the induction of virulence-related genes. Mycobacteria were exposed to different concentrations of nicotine then Mtb growth was evaluated. Subsequently, the expression of the virulence-related genes lysX, pirG, fad26, fbpa, ompa, hbhA, esxA, esxB, hspx, katG, lpqh, and caeA was evaluated by RT-qPCR. The effect of nicotine on intracellular Mtb was also evaluated. The results showed that nicotine promotes the growth of Mtb both extracellularly and intracellularly and increases the expression of genes related to virulence. In summary, nicotine promotes the growth of Mtb and the expression of virulence-related genes that could be correlated with the increased the risk of smokers developing TB.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 1 25%
Student > Bachelor 1 25%
Student > Master 1 25%
Unknown 1 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1 25%
Agricultural and Biological Sciences 1 25%
Immunology and Microbiology 1 25%
Unknown 1 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2023.
All research outputs
#14,819,917
of 23,996,152 outputs
Outputs from Microbiology and Immunology
#862
of 1,182 outputs
Outputs of similar age
#85,195
of 186,956 outputs
Outputs of similar age from Microbiology and Immunology
#1
of 4 outputs
Altmetric has tracked 23,996,152 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,182 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 186,956 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them