Title |
Delivering value from sperm proteomics for fertility
|
---|---|
Published in |
Cell and Tissue Research, June 2012
|
DOI | 10.1007/s00441-012-1452-2 |
Pubmed ID | |
Authors |
Aruna Govindaraju, Sule Dogan, Nelida Rodriguez-Osorio, Kamilah Grant, Abdullah Kaya, Erdogan Memili |
Abstract |
Fertilization of an egg by a spermatozoon sets the stage for mammalian development. Viable sperm are a prerequisite for successful fertilization and beyond. Spermatozoa have a unique cell structure where haploid genomic DNA is located in a tiny cytoplasmic space in the head, mitochondria in the midpiece and then the tail, all enclosed by several layers of membrane. Proteins in sperm play vital roles in motility, capacitation, fertilization, egg activation and embryo development. Molecular defects in these proteins are associated with low fertility or in some cases, infertility. This review will first summarize genesis, molecular anatomy and physiology of spermatozoa, fertilization, embryogenesis and then those proteins playing important roles in various aspects of sperm physiology. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 2% |
Switzerland | 1 | 2% |
Unknown | 45 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 21% |
Student > Master | 8 | 17% |
Researcher | 7 | 15% |
Student > Doctoral Student | 4 | 9% |
Lecturer | 3 | 6% |
Other | 7 | 15% |
Unknown | 8 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 17 | 36% |
Biochemistry, Genetics and Molecular Biology | 8 | 17% |
Medicine and Dentistry | 5 | 11% |
Veterinary Science and Veterinary Medicine | 4 | 9% |
Nursing and Health Professions | 1 | 2% |
Other | 0 | 0% |
Unknown | 12 | 26% |