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Enhancing NAD + salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease

Overview of attention for article published in Biology Open, February 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#2 of 599)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
12 news outlets
blogs
2 blogs
twitter
8 tweeters
facebook
10 Facebook pages

Readers on

mendeley
6 Mendeley
citeulike
1 CiteULike
Title
Enhancing NAD + salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease
Published in
Biology Open, February 2017
DOI 10.1242/bio.022186
Pubmed ID
Authors

Susann Lehmann, Samantha H. Y. Loh, L. Miguel Martins

Abstract

Familial forms of Parkinson's disease (PD) caused by mutations in PINK1 are linked to mitochondrial impairment. Defective mitochondria are also found in Drosophila models of PD with pink1 mutations. The co-enzyme nicotinamide adenine dinucleotide (NAD(+)) is essential for both generating energy in mitochondria and nuclear DNA repair through NAD(+)-consuming poly(ADP-ribose) polymerases (PARPs). We found alterations in NAD(+) salvage metabolism in Drosophila pink1 mutants and showed that a diet supplemented with the NAD(+) precursor nicotinamide rescued mitochondrial defects and protected neurons from degeneration. Additionally, a mutation of Parp improved mitochondrial function and was neuroprotective in the pink1 mutants. We conclude that enhancing the availability of NAD(+) by either the use of a diet supplemented with NAD(+) precursors or the inhibition of NAD(+)-dependent enzymes, such as PARPs, which compete with mitochondria for NAD(+) is a viable approach to preventing neurotoxicity associated with mitochondrial defects.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 50%
Student > Master 2 33%
Student > Postgraduate 1 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 83%
Pharmacology, Toxicology and Pharmaceutical Science 1 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 109. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2017.
All research outputs
#67,599
of 7,885,400 outputs
Outputs from Biology Open
#2
of 599 outputs
Outputs of similar age
#5,276
of 249,252 outputs
Outputs of similar age from Biology Open
#1
of 31 outputs
Altmetric has tracked 7,885,400 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 599 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,252 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.