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Redox Control of Leukemia: From Molecular Mechanisms to Therapeutic Opportunities

Overview of attention for article published in Antioxidants & Redox Signaling, April 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

twitter
1 tweeter
patent
1 patent
facebook
7 Facebook pages

Citations

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83 Dimensions

Readers on

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90 Mendeley
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Title
Redox Control of Leukemia: From Molecular Mechanisms to Therapeutic Opportunities
Published in
Antioxidants & Redox Signaling, April 2013
DOI 10.1089/ars.2011.4258
Pubmed ID
Authors

Mary E. Irwin, Nilsa Rivera-Del Valle, Joya Chandra

Abstract

Reactive oxygen species (ROS) play both positive and negative roles in the proliferation and survival of a cell. This dual nature has been exploited by leukemia cells to promote growth, survival, and genomic instability-some of the hallmarks of the cancer phenotype. In addition to altered ROS levels, many antioxidants are dysregulated in leukemia cells. Together, the production of ROS and the expression and activity of antioxidant enzymes make up the primary redox control of leukemia cells. By manipulating this system, leukemia cells gain proliferative and survival advantages, even in the face of therapeutic insults. Standard treatment options have improved leukemia patient survival rates in recent years, although relapse and the development of resistance are persistent challenges. Therapies targeting the redox environment show promise for these cases. This review highlights the molecular mechanisms that control the redox milieu of leukemia cells. In particular, ROS production by the mitochondrial electron transport chain, NADPH oxidase, xanthine oxidoreductase, and cytochrome P450 will be addressed. Expression and activation of antioxidant enzymes such as superoxide dismutase, catalase, heme oxygenase, glutathione, thioredoxin, and peroxiredoxin are perturbed in leukemia cells, and the functional consequences of these molecular alterations will be described. Lastly, we delve into how these pathways can be potentially exploited therapeutically to improve treatment regimens and promote better outcomes for leukemia patients.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 1%
Ireland 1 1%
Singapore 1 1%
Sri Lanka 1 1%
United States 1 1%
Unknown 85 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 22%
Researcher 17 19%
Student > Bachelor 11 12%
Student > Postgraduate 9 10%
Student > Master 8 9%
Other 13 14%
Unknown 12 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 33%
Biochemistry, Genetics and Molecular Biology 15 17%
Medicine and Dentistry 12 13%
Chemistry 4 4%
Arts and Humanities 2 2%
Other 9 10%
Unknown 18 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2017.
All research outputs
#2,497,481
of 11,927,464 outputs
Outputs from Antioxidants & Redox Signaling
#147
of 1,122 outputs
Outputs of similar age
#26,142
of 137,851 outputs
Outputs of similar age from Antioxidants & Redox Signaling
#10
of 40 outputs
Altmetric has tracked 11,927,464 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,122 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 137,851 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.