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Serum and cerebrospinal fluid immune mediators in children with autistic disorder: a longitudinal study

Overview of attention for article published in Molecular Autism, January 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

1 blog
32 tweeters
2 Facebook pages


55 Dimensions

Readers on

80 Mendeley
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Serum and cerebrospinal fluid immune mediators in children with autistic disorder: a longitudinal study
Published in
Molecular Autism, January 2017
DOI 10.1186/s13229-016-0115-7
Pubmed ID

Carlos A. Pardo, Cristan A. Farmer, Audrey Thurm, Fatma M. Shebl, Jorjetta Ilieva, Simran Kalra, Susan Swedo


The causes of autism likely involve genetic and environmental factors that influence neurobiological changes and the neurological and behavioral features of the disorder. Immune factors and inflammation are hypothesized pathogenic influences, but have not been examined longitudinally. In a cohort of 104 participants with autism, we performed an assessment of immune mediators such as cytokines, chemokines, or growth factors in serum and cerebrospinal fluid (n = 67) to determine potential influences of such mediators in autism. As compared with 54 typically developing controls, we found no evidence of differences in the blood profile of immune mediators supportive of active systemic inflammation mechanisms in participants with autism. Some modulators of immune function (e.g., EGF and soluble CD40 ligand) were increased in the autism group; however, no evidence of group differences in traditional markers of active inflammation (e.g., IL-6, TNFα, IL-1β) were observed in the serum. Further, within-subject stability (measured by estimated intraclass correlations) of most analytes was low, indicating that a single measurement is not a reliable prospective indicator of concentration for most analytes. Additionally, in participants with autism, there was little correspondence between the blood and CSF profiles of cytokines, chemokines, and growth factors, suggesting that peripheral markers may not optimally reflect the immune status of the central nervous system. Although the relatively high fraction of intrathecal production of selected chemokines involved in monocyte/microglia function may suggest a possible relationship with the homeostatic role of microglia, control data are needed for further interpretation of its relevance in autism. These longitudinal observations fail to provide support for the hypothesized role of disturbances in the expression of circulating cytokines and chemokines as an indicator of systemic inflammation in autism. ClinicalTrials.gov, NCT00298246.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 80 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 18%
Student > Bachelor 13 16%
Student > Ph. D. Student 10 13%
Researcher 8 10%
Other 5 6%
Other 10 13%
Unknown 20 25%
Readers by discipline Count As %
Neuroscience 17 21%
Biochemistry, Genetics and Molecular Biology 9 11%
Medicine and Dentistry 8 10%
Psychology 7 9%
Agricultural and Biological Sciences 5 6%
Other 9 11%
Unknown 25 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2019.
All research outputs
of 23,313,051 outputs
Outputs from Molecular Autism
of 678 outputs
Outputs of similar age
of 423,033 outputs
Outputs of similar age from Molecular Autism
of 12 outputs
Altmetric has tracked 23,313,051 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 678 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.2. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 423,033 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.