Title |
About the complexity of adult onset Still’s disease… and advances still required for its management
|
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Published in |
BMC Medicine, January 2017
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DOI | 10.1186/s12916-016-0769-1 |
Pubmed ID | |
Authors |
Philippe Guilpain, Alain Le Quellec |
Abstract |
Adult onset Still's disease (AOSD) is a rare inflammatory disorder that remains poorly understood. Its pathophysiology is yet to be completely elucidated, but is known to consist mainly on a cytokine cascade, responsible for the systemic manifestations. AOSD diagnosis is usually difficult and delayed, with physicians having to rule out several other conditions, including cancer or infectious diseases. Prognosis is heterogeneous and difficult to establish, ranging from benign outcome to chronic destructive polyarthritis and/or life-threatening events. In addition, treatment remains to be codified, especially considering the development of new drugs. In this commentary, we attempt to elucidate the complexity of AOSD and to highlight the need of working on prognostic tools for this disorder. We also discuss the numerous advances that would be useful for patients in the daily management of this disease.Please see related article: http://bmcmedicine.biomedcentral.com/articles/ 10.1186/s12916-016-0738-8 . |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
Spain | 1 | 25% |
United Kingdom | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 20% |
Student > Postgraduate | 3 | 15% |
Student > Bachelor | 2 | 10% |
Professor | 1 | 5% |
Student > Master | 1 | 5% |
Other | 3 | 15% |
Unknown | 6 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 45% |
Veterinary Science and Veterinary Medicine | 1 | 5% |
Immunology and Microbiology | 1 | 5% |
Agricultural and Biological Sciences | 1 | 5% |
Neuroscience | 1 | 5% |
Other | 1 | 5% |
Unknown | 6 | 30% |